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PARK2 protein, human

Known as: Parkinson disease (autosomal recessive, juvenile) 2, parkin, human, E3 Ubiquitin-Protein Ligase Parkin, Parkinson Disease Protein 2 
E3 ubiquitin-protein ligase parkin (465 aa, ~52 kDa) is encoded by the human PARK2 gene. This protein may play a role in the ubiquitination of… 
National Institutes of Health

Related topics

Related topics

11 relations
Cell DeathEnzyme GeneHomo sapiensLigase Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy
Mitophagy is an essential process for mitochondrial quality control and turnover. It is activated by two distinct pathways, one… 
Highly Cited
2015
Highly Cited
2015
Mechanism of phospho-ubiquitin induced PARKIN activation
The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal… 
Highly Cited
2015
Highly Cited
2015
A Ubl/ubiquitin switch in the activation of Parkin
Mutations in Parkin and PINK1 cause an inherited early‐onset form of Parkinson's disease. The two proteins function together in a… 
Highly Cited
2015
Highly Cited
2015
Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains.
Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease (AD). Mitophagy, a selective autophagy… 
Highly Cited
2012
Highly Cited
2012
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
Dysfunction of PINK1, a mitochondrial Ser/Thr kinase, causes familial Parkinson's disease (PD). Recent studies have revealed that… 
Highly Cited
2011
Highly Cited
2011
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Highly Cited
2010
Highly Cited
2010
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
Mitochondrial genomes with deleterious mutations can replicate in cells along with wild-type genomes in a state of heteroplasmy… 
Highly Cited
2010
Highly Cited
2010
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
Mitochondrial dysfunction is an early sign of many neurodegenerative diseases. Very recently, two Parkinson disease (PD… 
Highly Cited
2008
Highly Cited
2008
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.
Highly Cited
2005
Highly Cited
2005
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests… 
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