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Oxi8006
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.
Tracy E. Strecker
,
Samuel O. Odutola
,
+12 authors
M. L. Trawick
Cancer letters
2015
Corpus ID: 25946341
This study describes the vascular disrupting ability and the mechanism of action of the indole-based tubulin-binding compound…
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2015
2015
Vascular Disrupting Activity of OXi8006 in Endothelial Cells and Its Phosphate Prodrug OXi8007 in Breast Tumor Xenografts in Vivo
Samuel O. Odutola
,
T. E. Strecker
,
+12 authors
M. L. Trawick
2015
Corpus ID: 82210618
Tubulin-binding, small-molecule vascular disrupting agents (VDAs) are anticancer agents that rapidly depolymerize microtubules…
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2013
2013
Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole…
Matthew T Macdonough
,
Tracy E. Strecker
,
+4 authors
K. G. Pinney
Bioorganic & medicinal chemistry
2013
Corpus ID: 31811175
The discovery of a 2-aryl-3-aroyl indole-based small-molecule inhibitor of tubulin assembly (referred to as OXi8006) inspired the…
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2013
2013
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
M. Hadimani
,
Matthew T Macdonough
,
+15 authors
K. G. Pinney
Journal of natural products
2013
Corpus ID: 46336639
The natural products colchicine and combretastatin A-4 are potent inhibitors of tubulin assembly, and they have inspired the…
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2012
2012
Structural Modifications of OXi8006 Leading to New Indole-Based Anti-Cancer Agents
P. Hor
2012
Corpus ID: 102540156
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