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Org 26576 acts by modulating ionotropic AMPA-type glutamate receptors to enhance glutamatergic neurotransmission. The aim of this… Expand BACKGROUND
It has been posited that glutamate dysregulation contributes to the pathophysiology of attention-deficit/hyperactivity… Expand Brain derived neurotrophic factor (BDNF) is a key mediator of brain plasticity. The modulation of its expression and function is… Expand BackgroundA key challenge to dose selection in early central nervous system (CNS) clinical drug development is that patient… Expand IntroductionThe α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor potentiator Org 26576 represents an… Expand RationaleThe α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor positive allosteric modulators (AMPA-PAMs… Expand Ampakines have shown beneficial effects on cognition in selected animal models of learning. However, their ability to modify long… Expand RationaleCurrently available antidepressants upregulate hippocampal neurogenesis and prefrontal gliogenesis after chronic… Expand The ionotropic glutamate AMPA ((R,S)-α-amino-3-hydroxy-5-methyl-4isoxazolepropionic acid) receptor mediates the majority of… Expand AMPA receptor potentiating drugs (e.g. ampakines) enhance glutamatergic neurotransmission, and may have potential therapeutic… Expand