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Oraxol

Known as: Paclitaxel-HM30181 Methanesulfonate Monohydrate, Paclitaxel/HM30181A 
A combination formulation composed of a capsule containing the taxane compound paclitaxel and a tablet containing the multidrug resistance (MDR… 
National Institutes of Health

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Microtubule ProcessNCIt Antineoplastic Agent Terminology

Papers overview

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2020
2020
A phase II study of oraxol in the treatment of unresectable cutaneous angiosarcoma.
11517Background: Oraxol is a combination of oral paclitaxel and a novel oral P-glycoprotein inhibitor, HM30181A. Cutaneous… 
2019
2019
A phase Ib study of oraxol in combination with ramucirumab in patients with gastric or esophageal cancers who failed previous chemotherapy.
e15518 Background: Oraxol consists of oral paclitaxel (PTX) administered with the novel P-glycoprotein inhibitor HM30181A which… 
2019
2019
A pilot study of oral paclitaxel (ORAXOL) in subjects with cutaneous angiosarcomas (KX-ORAX-010)
Abstract Background Angiosarcomas (AS) are rare and aggressive tumors of endothelial cell origin. About half of patients present… 
2018
2018
A phase I study to evaluate safety, tolerability, pharmacokinetics and activity of oraxol in patients (pts) with advanced malignancies.
2526Background: Oraxol is an oral formulation of paclitaxel (PTX) co-administered with the potent, selective, poorly absorbed, P… 
2016
2016
An open label, randomised cross-over bioavailability study of oral paclitaxel (oraxol) compared to intravenous paclitaxel 80mg/m2.
2569Background: Paclitaxel has poor oral bioavailability due to the active excretion by p-glycoprotein (Pgp) present on… 
2013
2013
Application of mechanism-based PKPD model to identify optimal dosing regimens for future development of oraxol.
e13505 Background: Paclitaxel (PTX) is a widely used potent anticancer drug that blocks mitosis by stabilization of microtubules… 
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