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Oncolytic HSV1716

Known as: HSV1716 
A neuroattenuated, replication-restricted, ICP34.5 deleted (RL1 gene)-mutant herpes simplex virus (HSV) type I, constructed from wild-type strain 17… 
National Institutes of Health

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Related topics

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NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
High Mobility Group Box 1 Influences HSV1716 Spread and Acts as an Adjuvant to Chemotherapy
High Mobility Group Box 1 (HMGB1) is a multifunctional protein that plays various roles in the processes of inflammation, cancer… 
2017
2017
366PDOncolytic herpesvirus therapy for mesothelioma: A phase I/IIa trial of intrapleural administration of HSV1716 (NCT01721018)
2016
2016
Oncolytic HSV1716 in combination with targeted anti cancer agents : identification of synergistic interactions and their mechanisms of synergy
Oncolytic viruses are multifunctional cancer agents with huge clinical potential, and recently the first Herpes Simplex Virus… 
2016
2016
Abstract A14: Checkpoinblockade enhances oncolytic herpes virotherapy in immunosuppressive sarcoma models
Most solid tumors are characterized by an immunosuppressive microenvironment, limiting the effectiveness of antitumor… 
2015
2015
Immune responses following intrapleural administration of oncolytic SEPREHVIR in patients with malignant pleural mesothelioma
Meeting abstracts Malignant pleural mesothelioma (MPM) remains a major challenge, with limited therapeutic options. Multifocal… 
2013
2013
Oncolytic virotherapy for gliomas: steps toward the future.
389 ISSN 2045-0907 10.2217/CNS.13.35 © 2013 Future Medicine Ltd CNS Oncol. (2013) 2(5), 389–392 Oncolytic virotherapy is a… 
2010
2010
Abstract 2410: Development of a genetically-optimized whole tumor cell vaccine for ovarian cancer using HSV-derived glycoprotein D
Background: Dendritic cell (DC) vaccines offer a promising addition to standard treatment for ovarian cancer with surgery and… 
2006
2006
A phase 1 trial of the herpes simplex virus HSV1716 in patients with high grade glioma plus an in vitro investigation of the interaction between HSV1716 and ionising radiation
HSV1716 is a mutant herpes simplex virus with a deletion in both copies of the RL1 gene, that encodes the protein ICP34.5, a… 
2003
2003
Conditionally replicating viruses in cancer therapy
Conditionally replicating viruses (CRVs) offer the promise of a powerful weapon in our clinical arsenal against cancer. 1,2 Such… 
2002
2002
Oral Presentations
occurred. In the trial reported here, patients with high grade glioma had their tumours surgically resected and 10 pfu of the… 
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