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OSI-7904L

Known as: GS7904L, OSI 7904L, OSI-7904 liposomal 
A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor… Expand
National Institutes of Health

Papers overview

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2009
2009
e17005 Background: Given the limited efficacy and relative toxicity of chemotherapy for metastatic or recurrent squamous cell… Expand
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2008
2008
Purpose: To evaluate the safety and describe the pharmacokinetic profile of OSI-7904L, a novel liposomal thymidylate synthase… Expand
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2007
2007
SummaryThe prognosis of advanced biliary tract carcinoma is poor with chemotherapy limited to a palliative role. This randomised… Expand
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2007
2007
PurposeOSI-7904L is a liposomal formulation of a potent thymidylate synthase (TS) inhibitor. This phase I study evaluated the… Expand
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2006
2006
A two-stage Simon design was used to evaluate the response rate of OSI-7904L, a liposome encapsulated thymidylate synthase… Expand
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Review
2006
Review
2006
  • R. Wilson
  • The oncologist
  • 2006
  • Corpus ID: 41818754
Developments that may improve existing cytotoxic therapy for colorectal cancer (CRC) include alternatives to 5-fluorouracil (5-FU… Expand
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2005
2005
Purpose: OSI-7904L is a liposomal formulation of a potent noncompetitive thymidylate synthase inhibitor (TSI) that does not… Expand
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2005
2005
4042 Background: OSI-7904L is a liposomal TS inhibitor with increased plasma residence and superior preclinical antitumor… Expand
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2004
2004
OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] is a… Expand
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