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OPC 14117

Known as: 1-Piperazineacetamide, N-(2,3-dihydro-7-hydroxy-2,2,4,6-tetramethyl-1H-inden-1-yl)-4-(3-methoxyphenyl)-, OPC-14117 
National Institutes of Health

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2 relations

Broader (2)

IndansPiperazines

Papers overview

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2002
2002
Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat
2000
2000
NMDA and non-NMDA receptor-stimulated IkappaB-alpha degradation: differential effects of the caspase-3 inhibitor DEVD.CHO, ethanol and free radical scavenger OPC-14117.
The excitotoxic response of striatal neurons to NMDA and non-NMDA receptor agonists involves the nuclear translocation of… 
1998
1998
Antioxidant, OPC-14117, attenuates edema formation, and subsequent tissue damage following cortical contusion in rats.
Oxygen free radicals contribute to various kinds of tissue injury processes within the central nervous system. It has been… 
1998
1998
Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease. The Huntington Study Group.
Oxidative damage due to free-radical generation in the setting of underlying defects of neuronal energy metabolism has been… 
1998
1998
Chronic Exposure to MPTP as a Primate Model of Progressive Parkinsonism: A Pilot Study with a Free Radical Scavenger
The development of a validated primate model of progressive parkinsonism is a critical step in the evaluation of drugs that might… 
1997
1997
Protective effect of a novel free radical scavenger, OPC‐14117, on wobbler mouse motor neuron disease
A possible protective effect of a novel free radical scavenger, OPC‐14117, on the progressive motor neuron death in wobbler mice… 
1997
1997
Antioxidant, OPC-14117, attenuates edema formation and behavioral deficits following cortical contusion in rats.
Oxygen free radicals may contribute to tissue injury processes in the central nervous system following ischemia or trauma. Recent… 
1997
1997
Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders.
Cognitive impairment is a common and disabling complication of advanced HIV infection. Antiretroviral agents are the only proven… 
1991
1991
Evaluation of superoxide scavenging activity of OPC-14117 by electron spin resonance technique.
OPC-14117 is a potent drug which has both brain function activating effect and protective effect against cerebral ischemia… 
1991
1991
Novel cerebroprotective agents with central nervous system stimulating activity. 2. Synthesis and pharmacology of the 1-(acylamino)-7-hydroxyindan derivatives.
In a continuous search for a novel cerebroprotective drug with a central nervous system (CNS) stimulating activity, a series of 1… 
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