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ONO-6950

 
National Institutes of Health

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gemilukast

Papers overview

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2017
2017
A new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model.
Although the effectiveness of CysLT1 receptor antagonists on asthma has been clinically established, the effects of CysLT2… Expand
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2016
2016
A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma.
BACKGROUND The cysteinyl leukotrienes (cysLTs) play a key role in the pathophysiology of asthma. In addition to functioning as… Expand
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2015
2015
Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma.
We assessed in this study the anti-asthmatic effects of ONO-6950, a novel cysteinyl leukotriene 1 (CysLT1) and 2 (CysLT2… Expand
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2015
2015
Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction.
BACKGROUND The expression and functional role of CysLT2 receptors in asthma have not been clarified. In this study, we evaluated… Expand
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2015
2015
Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma.
An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and… Expand
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2014
2014
Late-breaking abstract: Effects of a dual CysLT1/2 antagonist, ONO-6950, on allergen-induced airway responses in subjects with mild allergic asthma
Background: The cysteinyl leukotrienes (CysLTs) play a key role in the pathophysiology of asthma. In addition to functioning as… Expand
Is this relevant?