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ON 01910

Known as: ON-01910, ON01910 
 
National Institutes of Health

Papers overview

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2019
2019
PURPOSE Squamous cell carcinoma (SCC) of the skin is the leading cause of death in patients with the severe generalized form of… Expand
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2018
2018
Inhibition of RAS-RAF-ERK-signaling is a major mechanism mediated by the multi-kinase inhibitors sorafenib and regorafenib, the… Expand
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2014
2014
ON01910.Na is a highly effective anticancer agent that induces mitotic arrest and apoptosis. Clinical studies with ON01910 in… Expand
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2013
2013
Polo-like kinase 1 (PLK1), one of the key regulators of mitosis, is a target for cancer therapy due to its abnormally high… Expand
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2012
2012
ABSTRACTPurposeTo evaluate a mitotic inhibitor, ON01910.Na, as a potential chemotherapeutic agent for brain tumors using a series… Expand
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2011
2011
ON01910 is a small molecular weight benzyl styryl sulfone currently under investigation as a novel anticancer agent. The purpose… Expand
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2010
2010
During the preclinical drug discovery process it remains a challenge to enable early elimination of candidate molecules that may… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE Antimitotic chemotherapy remains a cornerstone of multimodality treatment for locally advanced and metastatic cancers. To… Expand
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Review
2009
Review
2009
Purpose:Antimitotic chemotherapy remains a cornerstone of multimodality treatment for locally advanced andmetastatic cancers.To… Expand
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Highly Cited
2005
Highly Cited
2005
Elevated expression of polo-like kinase1 (Plk1) has been reported in many human tumors, and inhibition of Plk1 activity results… Expand
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