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OKN 007

Known as: OKN-007, 2,4-Disulfonyl PBN, OKN007 
A disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), with potential anti-glioma activity. Although the exact mechanism(s) of action of OKN007… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzenesulfonatesImines
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
OKN-007 decreases VEGFR-2 levels in a preclinical GL261 mouse glioma model.
Angiogenesis is essential to tumor progression, and the precise imaging of the angiogenic marker vascular endothelial growth… 
2008
2008
Electron paramagnetic resonance spin trapping of glutathiyl radicals by PBN in the presence of cyclodextrins and by PBN attached to beta-cyclodextrin.
The reaction of the glutathiyl radical (GS*) with a widely used spin trap N- tert-butyl-alpha-phenylnitrone (PBN) has been… 
2007
2007
Increased sensitivity to transient global ischemia in aging rat brain.
Transient global brain ischemia induced by cardiac arrest and resuscitation (CAR) results in reperfusion injury associated with… 
2001
2001
Free radical spin trap alpha-phenyl-N-tert-butyl-nitron inhibits caspase-3 activation and reduces brain damage following a severe forebrain ischemic injury.
2000
2000
Do spin traps also act as classical chain-breaking antioxidants? A quantitative kinetic study of phenyl tert-butylnitrone (PBN) in solution and in liposomes.
Highly Cited
1999
Highly Cited
1999
Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl N-tert-butylnitrone (PBN).
The spin-trapping compound phenyl N-tert-butylnitrone (PBN) affords protection from the lethality of septic shock in rodents… 
1996
1996
Free radicals and taste aversion learning in the rat; Nitric oxide, radiation and dopamine
1990
1990
Mass spectroscopy and chromatography of the trichloromethyl radical adduct of phenyl tert-butyl nitrone.
Positive structural identification of the PBN-trichloromethyl spin adduct in vitro was accomplished with the use of high pressure… 
1989
1989
Spin trapping of free radicals produced in vivo in heart and liver during endotoxemia.
Studies using free radical scavengers and measurements of lipid peroxidation have suggested that free radicals are generated… 
1986
1986
The significance of optokinetic nystagmus asymmetry in hemispheric lesions
Since the localizing value of optokinetic nystagmus (OKN) in cerebral hemispheric lesions has been questioned by some… 
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