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Nucleoside Reverse Transcriptase Inhibitor

Known as: NRTI, Nucleoside Analog Reverse Transcriptase Inhibitor 
A substance with a structure similar to a nucleoside molecule that is capable of occupying the active catalytic site of a reverse transcriptase… 
National Institutes of Health

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Nucleoside Reverse Transcriptase Inhibitors [MoA]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.
Nucleoside reverse transcriptase inhibitors (NRTIs), essential components of combinational therapies used for treatment of human… 
2007
2007
Relationship of Mitochondrial DNA Depletion and Respiratory Chain Activity in Preadipocytes treated with Nucleoside Reverse Transcriptase Inhibitors
Objective To study the impact of adipocyte differentiation on nucleoside reverse transcriptase inhibitor (NRTI)-mediated… 
2006
2006
Novel Nonnucleoside Inhibitors That Select Nucleoside Inhibitor Resistance Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
ABSTRACT Mutations in and around the catalytic site of the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV… 
2005
2005
In Vitro Activity of SPD754, a New Deoxycytidine Nucleoside Reverse Transcriptase Inhibitor (NRTI), against 215 HIV-1 Isolates Resistant to Other NRTIs
SPD754 (also known as AVX-754) is a deoxycytidine analogue nucleoside reverse transcriptase inhibitor (NRTI) with antiretroviral… 
2005
2005
Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human…
ABSTRACT The development of antiviral drug resistance is an important problem in the treatment of human immunodeficiency virus… 
2005
2005
Mitochondrial Toxicity of Nucleoside Analogues in Primary Human Lymphocytes
Objective To evaluate if nucleoside analogue reverse transcriptase inhibitors (NRTIs) and polymerase-gamma inhibitors deplete… 
2004
2004
Therapeutic drug monitoring of lopinavir/ritonavir given alone or with a non-nucleoside reverse transcriptase inhibitor.
AIMS To evaluate the interindividual variability in the plasma concentrations of lopinavir in the context of routine monitoring… 
Review
2003
Review
2003
Long-term complications of nucleoside reverse transcriptase inhibitor therapy.
HAART has resulted in dramatic declines in morbidity and mortality among patients infected with HIV. Increased experience with… 
2003
2003
HIV-1 Resistance Profile of the Novel Nucleoside Reverse Transcriptase Inhibitor β-D-2′,3′-Dideoxy-2′,3′-Didehydro-5-Fluorocytidine (Reverset™)
Nucleoside reverse transcriptase inhibitors (NRTIs) represent the cornerstone of highly active antiretroviral therapy when… 
2001
2001
Development and validation of a reverse-phase HPLC method for analysis of efavirenz and its related substances in the drug substance and in a capsule formulation.
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