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Nucleoside Reverse Transcriptase Inhibitor

Known as: NRTI, Nucleoside Analog Reverse Transcriptase Inhibitor 
A substance with a structure similar to a nucleoside molecule that is capable of occupying the active catalytic site of a reverse transcriptase… 
National Institutes of Health

Related topics

Related topics

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Nucleoside Reverse Transcriptase Inhibitors [MoA]

Papers overview

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Highly Cited
2007
Highly Cited
2007
Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in… 
Highly Cited
2007
Highly Cited
2007
Evidence of a decline in transmitted HIV-1 drug resistance in the United Kingdom
Objective:To examine recent trends in transmitted drug resistance (TDR) in the United Kingdom. Methods:Analysis of results of… 
Highly Cited
2007
Highly Cited
2007
Frequent methamphetamine use is associated with primary non-nucleoside reverse transcriptase inhibitor resistance
We determined whether methamphetamine use is associated with the increased prevalence of primary HIV drug resistance among a… 
Highly Cited
2006
Highly Cited
2006
A high incidence of nucleoside reverse transcriptase inhibitor (NRTI)-induced lactic acidosis in HIV-infected patients in a South African context.
OBJECTIVE To determine the incidence of and predisposing risk factors for lactic acidosis in HIV-infected patients on… 
Highly Cited
2006
Highly Cited
2006
Virological response to a triple nucleoside/nucleotide analogue regimen over 48 weeks in HIV-1-infected adults in Africa
Objectives:To evaluate virologic response up to 48 weeks, and emergence of HIV-1 resistance mutations at 24 weeks, in therapy… 
Highly Cited
2006
Highly Cited
2006
Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action
ABSTRACT We have discovered a novel class of human immunodeficiency virus (HIV) reverse transcriptase (RT) inhibitors that block… 
2004
2004
Therapeutic drug monitoring of lopinavir/ritonavir given alone or with a non-nucleoside reverse transcriptase inhibitor.
AIMS To evaluate the interindividual variability in the plasma concentrations of lopinavir in the context of routine monitoring… 
Review
2003
Review
2003
HIV Resistance to Nevirapine and Other Non‐Nucleoside Reverse Transcriptase Inhibitors
&NA; Nevirapine and other members of the non‐nucleoside reverse transcriptase inhibitor (NNRTI) family of anti‐HIV‐1 drugs are… 
Review
2003
Review
2003
Long-term complications of nucleoside reverse transcriptase inhibitor therapy.
HAART has resulted in dramatic declines in morbidity and mortality among patients infected with HIV. Increased experience with… 
Highly Cited
2001
Highly Cited
2001
Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy
BackgroundEnhanced susceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI) was recently described in… 
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