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Noxythiolin

Known as: N-Methyl-N''-(hydroxymethyl)thiourea, Noxitiolin, Thiourea, N-(hydroxymethyl)-N'-methyl- 
Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (1)

Anti-Infective Agents, Local
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

Noxyflex-S

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1989
1989
[Adjuvant treatment of tubal surgery. Randomized prospective study of systemically administered corticoids and noxythiolin].
The effectiveness of systemic corticosteroids in the prevention of adhesion formation and reformation has been recently… 
1986
1986
Decrease in adherence of bacteria and yeasts to human mucosal epithelial cells by noxythiolin in vitro.
Adherence of buccal and vaginal isolates of Candida albicans to buccal epithelial cells and the adherence of urine isolates of… 
Highly Cited
1984
Highly Cited
1984
The efficacy of agents employed to prevent anastomotic recurrence in colorectal carcinoma.
Forty-eight of 72 surgeons canvassed in the South West of England (67%) routinely use an intraluminal cytotoxic agent to prevent… 
1983
1983
Mechanisms of antibacterial formaldehyde delivery from noxythiolin and other ‘masked‐formaldehyde’ compounds
Formaldehyde release in aqueous solutions of noxythiolin (N‐methyl‐N'‐hydroxymethyl thiourea) has been monitored by nuclear… 
1979
1979
Noxythiolin (Noxyflex), aprotinin (Trasylol) and peritoneal adhesion formation: An experimental study in the rat
Clinical and experimental studies have suggested that noxythiolin and aprotinin may prevent intraperitoneal adhesion formation. A… 
1978
1978
Topical noxythiolin in colonic healing
Rats were subjected to division and anastomosis of the colon just proximal to the rectum to study the healing of colonic… 
Review
1972
Review
1972
Treatment of peritonitis with per‐ and postoperative irrigation of the peritoneal cavity with noxythiolin solution
The present paper describes a technique for irrigating the peritoneal cavity in severe peritonitis, both at the time of… 
1971
1971
Topical noxythiolin antisepsis. Report of a controlled trial
Noxythiolin powder, 600 mg., deposited in the layers of the abdominal wall of right iliac fossa musclesplitting incisions after… 
Highly Cited
1970
Highly Cited
1970
Intraperitoneal noxythiolin in faecal peritonitis
Noxythiolin is a simple chemical compound which undergoes slow decomposition to liberate free formaldehyde. It is relatively non… 
1965
1965
Release of formaldehyde from polynoxylin and noxythiolin
Polynoxylin and noxythiolin (Anaflex and Noxyflex) have been recommended for the treatment of certain bacterial infections. Both… 
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