Notch Receptor Intracellular Domain

Known as: Neurogenic Locus Notch Homolog Protein Intracellular Domain, Notch ICD, Notch Intracellular Domain 
The free carboxy-terminal intracellular domain (ICD) of a notch family protein, which is a product of regulated intramembrane proteolysis mediated by… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
During chronic injury, regeneration of the adult liver becomes impaired. In this context bipotent Hepatic Progenitor Cells (HPCs… (More)
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Highly Cited
2007
Highly Cited
2007
gamma-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The epidermal growth factor receptor (EGFR) and Notch signaling pathways have been implicated in self-renewal of… (More)
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Highly Cited
2006
Highly Cited
2006
Mammalian epidermis consists of a basal layer of proliferative progenitors that gives rise to multiple differentiating layers to… (More)
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Highly Cited
2004
Highly Cited
2004
Notch signaling releases the Notch receptor intracellular domain (ICD), which complexes with CBF1 and Mastermind (MAM) to… (More)
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Highly Cited
2003
Highly Cited
2003
The Notch and transforming growth factor-beta (TGF-beta) signaling pathways play critical roles in the control of cell fate… (More)
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Highly Cited
2001
Highly Cited
2001
The beta-amyloid precursor protein (APP) is a ubiquitous receptor-like molecule without a known function. However, the recent… (More)
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Highly Cited
2000
Highly Cited
2000
Endocytosis of the ligand delta; is required for activation of the receptor Notch during Drosophila development. The Notch… (More)
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Highly Cited
1999
Highly Cited
1999
Signalling through the receptor protein Notch, which is involved in crucial cell-fate decisions during development, requires… (More)
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Highly Cited
1998
Highly Cited
1998
Notch proteins are ligand-activated transmembrane receptors involved in cell-fate selection throughout development. No known… (More)
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