Notch Receptor Intracellular Domain

Known as: Neurogenic Locus Notch Homolog Protein Intracellular Domain, Notch ICD, Notch Intracellular Domain 
The free carboxy-terminal intracellular domain (ICD) of a notch family protein, which is a product of regulated intramembrane proteolysis mediated by… (More)
National Institutes of Health

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Transcriptional Regulation

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Highly Cited
2012
Highly Cited
2012
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
During chronic injury, regeneration of the adult liver becomes impaired. In this context bipotent Hepatic Progenitor Cells (HPCs… (More)
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Highly Cited
2007
Highly Cited
2007
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
gamma-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy… (More)
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Highly Cited
2007
Highly Cited
2007
Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways.
BACKGROUND The epidermal growth factor receptor (EGFR) and Notch signaling pathways have been implicated in self-renewal of… (More)
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Highly Cited
2006
Highly Cited
2006
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Mammalian epidermis consists of a basal layer of proliferative progenitors that gives rise to multiple differentiating layers to… (More)
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Highly Cited
2004
Highly Cited
2004
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Notch signaling releases the Notch receptor intracellular domain (ICD), which complexes with CBF1 and Mastermind (MAM) to… (More)
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Highly Cited
2003
Highly Cited
2003
Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
The Notch and transforming growth factor-beta (TGF-beta) signaling pathways play critical roles in the control of cell fate… (More)
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Highly Cited
2001
Highly Cited
2001
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
The beta-amyloid precursor protein (APP) is a ubiquitous receptor-like molecule without a known function. However, the recent… (More)
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Highly Cited
2000
Highly Cited
2000
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway.
Endocytosis of the ligand delta; is required for activation of the receptor Notch during Drosophila development. The Notch… (More)
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Highly Cited
1999
Highly Cited
1999
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
Signalling through the receptor protein Notch, which is involved in crucial cell-fate decisions during development, requires… (More)
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Highly Cited
1998
Highly Cited
1998
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
Notch proteins are ligand-activated transmembrane receptors involved in cell-fate selection throughout development. No known… (More)
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