Nitroimidazole [EPC]

Known as: Nitroimidazole, Nitroimidazole-class Agent 
 
National Institutes of Health

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Nitroimidazoles

Papers overview

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Review
2011
Review
2011
Development of novel drugs for human African trypanosomiasis.
Human African trypanosomiasis (HAT) or 'sleeping sickness' is a neglected tropical disease caused by the parasite Trypanosoma… (More)
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2011
2011
Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness.
Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human… (More)
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Highly Cited
2010
Highly Cited
2010
Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness
BACKGROUND Human African trypanosomiasis (HAT), also known as sleeping sickness, is a fatal parasitic disease caused by… (More)
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2009
2009
Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases).
Infections with Giardia lamblia, Entamoeba histolytica, and Trichomonas vaginalis, which cause diarrhea, dysentery, and vaginitis… (More)
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Review
2007
Review
2007
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.
Current knowledge of the biochemistry of Trypanosoma cruzi has led to the development of new drugs and the understanding of their… (More)
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2007
2007
Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase
Metronidazole, a 5-nitroimidazole drug, has been the gold standard for several decades in the treatment of infections with… (More)
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Review
1998
Review
1998
Clinical and microbiological aspects of Trichomonas vaginalis.
Trichomonas vaginalis, a parasitic protozoan, is the etiologic agent of trichomoniasis, a sexually transmitted disease (STD) of… (More)
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1995
1995
Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide].
One of the most sensitive hypoxia detection methods is based on the observation that binding of nitroimidazoles to cellular… (More)
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Review
1993
Review
1993
Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action.
 
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Review
1993
Review
1993
Nitroimidazole drugs--action and resistance mechanisms. II. Mechanisms of resistance.
 
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