Nitric Oxide Synthase Type I

Known as: Neural Constitutive Nitric Oxide Synthase, nNOS Enzyme, Neuronal Nitric Oxide Synthase 
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.
National Institutes of Health

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In BloodNOS1 geneProcess of secretionantagonists & inhibitors
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NOS1 protein, humanNos1 protein, rat

Papers overview

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Highly Cited
2011
Highly Cited
2011
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
BACKGROUND We report clinical safety and biochemical efficacy from a dose-ranging study of intravenously administered AVI-4658… (More)
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Highly Cited
2006
Highly Cited
2006
NMDA Receptor-Nitric Oxide Transmission Mediates Neuronal Iron Homeostasis via the GTPase Dexras1
Dexras1 is a 30 kDa G protein in the Ras subfamily whose discovery was based on its pronounced inducibility by the glucocorticoid… (More)
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Highly Cited
2005
Highly Cited
2005
Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium.
Null mutation of dystrophin causes the lethal pathology of Duchenne muscular dystrophy (DMD) in which there is progressive… (More)
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Highly Cited
2004
Highly Cited
2004
Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling.
Although interactions between superoxide (O(2)(.-)) and nitric oxide underlie many physiologic and pathophysiologic processes… (More)
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Highly Cited
2003
Highly Cited
2003
Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling.
A neuronal isoform of nitric oxide synthase (nNOS) has recently been located to the cardiac sarcoplasmic reticulum (SR… (More)
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Highly Cited
2001
Highly Cited
2001
Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase.
Genetically engineered mice with targeted disruption of the neuronal nitric oxide synthase (nNOS) gene established the inhibitory… (More)
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Highly Cited
1999
Highly Cited
1999
Selective nitrergic neurodegeneration in diabetes mellitus - a nitric oxide-dependent phenomenon.
1. In vitro and in vivo studies have demonstrated a dysfunctional nitrergic system in diabetes mellitus, thus explaining the… (More)
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Highly Cited
1996
Highly Cited
1996
Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion.
Infarct volume and edema were assessed after transient focal ischemia in mice lacking neuronal nitric oxide synthase (NOS) gene… (More)
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Highly Cited
1996
Highly Cited
1996
Relationship of neuronal nitric oxide synthase immunoreactivity to GnRH neurons in the ovariectomized and intact female rat.
The present study has used a rat neuronal nitric oxide synthase (nNOS) antibody to examine the relationship of nNOS… (More)
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Highly Cited
1995
Highly Cited
1995
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.
Several studies suggest that nitric oxide (NO.) contributes to cell death following activation of NMDA receptors in cultured… (More)
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