Nicotinamide-Nucleotide Adenylyltransferase

Known as: ATP NMN Adenylyltransferase, NMN Adenylyltransferase, Adenylyltransferase, NMN 
An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The… (More)
National Institutes of Health

Papers overview

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2012
2012
Axons damaged by acute injury, toxic insults, or during neurodegenerative diseases undergo Wallerian or Wallerian-like… (More)
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Review
2010
Review
2010
Sirtuins comprise a family of NAD(+)-dependent protein deacetylases and ADP-ribosyltransferases. Mammalian SIRT1 - a homolog of… (More)
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Highly Cited
2009
Highly Cited
2009
Studies of naturally occurring mutant mice, wld(s), showing delayed Wallerian degeneration phenotype, suggest that axonal… (More)
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Highly Cited
2008
Highly Cited
2008
Neurodegeneration can be triggered by genetic or environmental factors. Although the precise cause is often unknown, many… (More)
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Highly Cited
2006
Highly Cited
2006
Axonal degeneration occurs in many neurodegenerative diseases and after traumatic injury and is a self-destructive program… (More)
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Highly Cited
2005
Highly Cited
2005
Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the NAD biosynthetic pathway. Three human NMNAT… (More)
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Highly Cited
2005
Highly Cited
2005
Axon degeneration occurs frequently in neurodegenerative diseases and peripheral neuropathies. Important insight into the… (More)
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Highly Cited
2003
Highly Cited
2003
Mice deficient in the peripheral myelin component P0 mimic severe forms of inherited peripheral neuropathies in humans, with… (More)
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Highly Cited
2001
Highly Cited
2001
Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but axons in the C57BL/WldS mouse are… (More)
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1995
1995
NMN adenylyltransferase (NMNAT) reversibly catalyzes the synthesis of NAD+ or NaAD+ from ATP and NMN or NaMN. In this work, we… (More)
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