Nicotinamide-Nucleotide Adenylyltransferase

Known as: ATP NMN Adenylyltransferase, NMN Adenylyltransferase, Adenylyltransferase, NMN 
An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The… (More)
National Institutes of Health

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Nicotinate-nucleotide adenylyltransferase

Papers overview

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2012
2012
A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity
Axons damaged by acute injury, toxic insults, or during neurodegenerative diseases undergo Wallerian or Wallerian-like… (More)
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Review
2010
Review
2010
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions.
Sirtuins comprise a family of NAD(+)-dependent protein deacetylases and ADP-ribosyltransferases. Mammalian SIRT1 - a homolog of… (More)
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Highly Cited
2009
Highly Cited
2009
Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.
Studies of naturally occurring mutant mice, wld(s), showing delayed Wallerian degeneration phenotype, suggest that axonal… (More)
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Highly Cited
2008
Highly Cited
2008
NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration
Neurodegeneration can be triggered by genetic or environmental factors. Although the precise cause is often unknown, many… (More)
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Highly Cited
2006
Highly Cited
2006
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy.
Axonal degeneration occurs in many neurodegenerative diseases and after traumatic injury and is a self-destructive program… (More)
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Highly Cited
2005
Highly Cited
2005
Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms.
Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the NAD biosynthetic pathway. Three human NMNAT… (More)
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Highly Cited
2005
Highly Cited
2005
A local mechanism mediates NAD-dependent protection of axon degeneration
Axon degeneration occurs frequently in neurodegenerative diseases and peripheral neuropathies. Important insight into the… (More)
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Highly Cited
2003
Highly Cited
2003
The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy.
Mice deficient in the peripheral myelin component P0 mimic severe forms of inherited peripheral neuropathies in humans, with… (More)
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Highly Cited
2001
Highly Cited
2001
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene
Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but axons in the C57BL/WldS mouse are… (More)
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1995
1995
Assay methods for nicotinamide mononucleotide adenylyltransferase of wide applicability.
NMN adenylyltransferase (NMNAT) reversibly catalyzes the synthesis of NAD+ or NaAD+ from ATP and NMN or NaMN. In this work, we… (More)
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