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Nesvacumab

Known as: Anti-ANG2 MOAB REGN910, REGN910 
A fully human monoclonal antibody directed against angiopoietin 2 (ANG2) with potential antiangiogenic and antineoplastic activities. Nesvacumab… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
ABSTRACT Introduction: The Tie-2/Angiopoietin pathway is a therapeutic target for the treatment of neovascular age-related… Expand
Review
2017
Review
2017
ABSTRACT Introduction: Evolving anti-vascular endothelial growth factor (VEGF) treatments for neovascular age-related macular… Expand
2016
2016
Phase III clinical trials evaluating bevacizumab (an antibody to the angiogenic ligand, VEGF-A) in breast cancer have found… Expand
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2015
2015
Purpose: Nesvacumab (REGN910) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and… Expand
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2014
2014
2540 Background: Nesvacumab (N) is an Ang2 selective, human MAb that potently blocks signaling through the Tie2 receptor… Expand
2014
2014
2522 Background: Nesvacumab (N) is a selective, human Ang-2 MAb, that potently blocks Ang2 signaling through the Tie2 receptor… Expand
Highly Cited
2013
Highly Cited
2013
The angiopoietins Ang1 (ANGPT1) and Ang2 (ANGPT2) are secreted factors that bind to the endothelial cell-specific receptor… Expand
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2013
2013
2517 Background: REGN910 is a selective, fully human Ang2 MAb that potently blocks signaling through the Tie2 receptor regulating… Expand
2013
2013
TPS2618 Background: REGN910 is a selective, fully human Angiopoietin-2 (ANG-2) MAb, which potently blocks signaling through the… Expand
2011
2011
TPS159 Background: Angiopoietin-2 (Ang2) is a secreted growth factor that functions as a critical regulator of angiogenesis… Expand