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Nelipepimut-S

Known as: L-Leucine, L-lysyl-L-isoleucyl-L-phenylalanylglycyl-L-seryl-L-leucyl-L-alanyl-L- phenylalanyl-, E75 Peptide, Human Receptor Tyrosine-Protein Kinase erbB-2 (Proto-Oncogene Neu, Tyrosine Kinase- type Cell Surface Receptor HER2, CD340)-(347-355)-Peptide 
A cancer vaccine comprised of a human leukocyte antigen (HLA) A2/A3 restricted HER2/neu (human epidermal growth factor receptor 2; ErbB2) nonapeptide… 
National Institutes of Health

Papers overview

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2016
2016
An observational study evaluating the expression of HER2 (1+, 2+, and 3+) with HLA A2/A3+ in gastric adenocarcinoma patients.
18 Background: Gastric cancer remains a major health issue and results in 800,000 annual deaths worldwide. Despite approximately… 
2011
2011
OT3-01-18: Combination Immunotherapy with Trastuzumab and the HER2 Vaccine E75 in Low and Intermediate HER2−Expressing Breast Cancer Patients To Prevent Recurrence.
Background In a phase II trial, the HER2−derived E75 vaccine administered with the immunoadjuvant GM-CSF has been shown to reduce… 
2010
2010
Abstract P2-20-01: Safety and Clinical Efficacy of Multiple Booster Inoculations with the E75 Adjuvant Breast Cancer Vaccine
Background: We are conducting clinical trials of the HER2 /neu E75-peptide+GM-CSF vaccine in clinically disease-free breast… 
Review
2008
Review
2008
Combined ClinicalTrial Results of a HER2/neu (E75) Vaccine for the Prevention of Recurrence in High-Risk Breast Cancer Patients: U.S. Military Cancer Institute ClinicalTrials Group Study I-01and I-02
Purpose: E75 is an immunogenic peptide from the HER2/neu protein, which is overexpressed in many breast cancer patients.We have… 
2007
2007
Preliminary breast cancer vaccine study shows promise.
A vaccine designed to treat breast cancer has performed surprisingly well in an initial clinical study. In a phase II trial of… 
2006
2006
Correlations between SerumMonocyte Chemotactic Protein-1 Levels, Clinical Prognostic Factors, and HER-2/neu Vaccine-Related Immunity inBreastCancerPatients
Purpose:We studied serum monocyte chemotactic protein-1 (MCP-1) levels in breast cancer patients in relationship to their… 
2004
2004
Comparison of immunological responses in node-positive and node-negative breast cancer patients receiving a HER2/neu E75 peptide vaccine
1992
1992
Bidirectional Regulation of the 1,25=Dihydroxyvitamin Da Receptor by Phorbol Ester-Activated Protein Kinase- C in Osteoblast-Like Cells: Interaction with Adenosine
In the present study the involvement of protein kinase-C (PKC) in the regulation of the vitamin D receptor (VDR) and interaction… 
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