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Negative Elongation Factor A Protein

Known as: NELF-A, Negative Elongation Factor A, Wolf-Hirschhorn Syndrome Candidate 2 Protein 
Negative elongation factor A (528 aa, ~57 kDa) is encoded by the human WHSC2 gene. This protein plays a role in transcriptional elongation.
National Institutes of Health

Related topics

Related topics

6 relations
Genes, RegulatorNELFA geneTranscriptional RegulationWHSC2 wt Allele

Broader (1)

negative elongation factor

Papers overview

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2017
2017
Molecular Ecological Basis of Grasshopper (Oedaleus asiaticus) Phenotypic Plasticity under Environmental Selection
While ecological adaptation in insects can be reflected by plasticity of phenotype, determining the causes and molecular… 
2016
2016
Architecture and RNA binding of the human negative elongation factor
Transcription regulation in metazoans often involves promoter-proximal pausing of RNA polymerase (Pol) II, which requires the 4… 
Highly Cited
2016
Highly Cited
2016
Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II
The association of DSIF and NELF with initiated RNA Polymerase II (Pol II) is the general mechanism for inducing promoter… 
2014
2014
A Kinase-Independent Activity of Cdk9 Modulates Glucocorticoid Receptor-Mediated Gene Induction
A gene induction competition assay has recently uncovered new inhibitory activities of two transcriptional cofactors, NELF-A and… 
2013
2013
A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-regulated Gene Induction Properties*
Background: Understanding glucocorticoid receptor (GR)-regulated gene transcription requires detailed description of cofactor… 
2012
2012
Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome.
Wolf-Hirschhorn syndrome (WHS) is a contiguous gene deletion disorder associated with the distal part of the short arm of… 
2012
2012
Identification of Location and Kinetically Defined Mechanism of Cofactors and Reporter Genes in the Cascade of Steroid-regulated Transactivation*
Background: Current descriptions of steroid hormone action are largely phenomenological rather than mechanistic. Results… 
2011
2011
Mechanism of Glycyrrhizic Acid Inhibition of Kaposi's Sarcoma-Associated Herpesvirus: Disruption of CTCF-Cohesin-Mediated RNA Polymerase II Pausing and Sister Chromatid Cohesion
ABSTRACT Glycyrrhizic acid (GA), a derivative of licorice, selectively inhibits the growth of lymphocytes latently infected with… 
Highly Cited
2009
Highly Cited
2009
Human Negative Elongation Factor Activates Transcription and Regulates Alternative Transcription Initiation*
The human negative elongation factor (NELF) is a four-subunit protein complex that inhibits the movement of RNA polymerase II… 
Highly Cited
2003
Highly Cited
2003
Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex
ABSTRACT The multisubunit transcription elongation factor NELF (for negative elongation factor) acts together with DRB (5,6… 
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