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Negative Elongation Factor A Protein

Known as: NELF-A, Negative Elongation Factor A, Wolf-Hirschhorn Syndrome Candidate 2 Protein 
Negative elongation factor A (528 aa, ~57 kDa) is encoded by the human WHSC2 gene. This protein plays a role in transcriptional elongation.
National Institutes of Health

Related topics

Related topics

6 relations
Genes, RegulatorNELFA geneTranscriptional RegulationWHSC2 wt Allele

Broader (1)

negative elongation factor

Papers overview

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2017
2017
Molecular Ecological Basis of Grasshopper (Oedaleus asiaticus) Phenotypic Plasticity under Environmental Selection
While ecological adaptation in insects can be reflected by plasticity of phenotype, determining the causes and molecular… 
Highly Cited
2016
Highly Cited
2016
Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II
The association of DSIF and NELF with initiated RNA Polymerase II (Pol II) is the general mechanism for inducing promoter… 
2015
2015
Structural and functional studies on the negative elongation factor
In many metazoans RNA polymerase II is stably paused after transcribing 20-60 nucleotides of a gene and awaits controlled release… 
2012
2012
Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome.
Wolf-Hirschhorn syndrome (WHS) is a contiguous gene deletion disorder associated with the distal part of the short arm of… 
2011
2011
Mechanism of Glycyrrhizic Acid Inhibition of Kaposi's Sarcoma-Associated Herpesvirus: Disruption of CTCF-Cohesin-Mediated RNA Polymerase II Pausing and Sister Chromatid Cohesion
ABSTRACT Glycyrrhizic acid (GA), a derivative of licorice, selectively inhibits the growth of lymphocytes latently infected with… 
Highly Cited
2003
Highly Cited
2003
Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex
ABSTRACT The multisubunit transcription elongation factor NELF (for negative elongation factor) acts together with DRB (5,6… 
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