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Narcolepsy

Known as: excessive uncontrollable daytime sleepiness, Gelineaus Syndrome, Narcolepsy NOS 
A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with… Expand
National Institutes of Health

Related topics

Related topics

35 relations
24 HR Methylphenidate Hydrochloride 27 MG Extended Release Oral Tablet24 HR Methylphenidate Hydrochloride 36 MG Extended Release Oral Tablet24 HR Methylphenidate Hydrochloride 54 MG Extended Release Oral Tablet30/70 Release 24 HR Methylphenidate Hydrochloride 10 MG Extended Release Oral Capsule [Metadate]
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Broader (4)

CNS disorderDyssomniasSleep Disordersnervous system disorder

Narrower (2)

Irresistible sleepiness, cataplexy and onset of sleep in desynchronized phaseNarcolepsy-Cataplexy Syndrome

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases
Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral… Expand
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Review
2018
Review
2018
Histamine pharmacology: from Sir Henry Dale to the 21st century
Histamine has been one of the most studied substances in medicine, playing a major role in diverse (patho)physiological processes… Expand
Review
2018
Review
2018
Hypocretin as a Hub for Arousal and Motivation
The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to integrate and regulate sleep, feeding… Expand
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Highly Cited
2001
Highly Cited
2001
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss… Expand
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Highly Cited
2000
Highly Cited
2000
Hypocretin (orexin) deficiency in human narcolepsy
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was… Expand
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Highly Cited
2000
Highly Cited
2000
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In… Expand
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Highly Cited
2000
Highly Cited
2000
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
We explored the role of hypocretins in human narcolepsy through histopathology of six narcolepsy brains and mutation screening of… Expand
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Highly Cited
1999
Highly Cited
1999
Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral hypothalamus and send axons to… Expand
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Highly Cited
1999
Highly Cited
1999
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized by daytime sleepiness, cataplexy, and… Expand
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Highly Cited
1991
Highly Cited
1991
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
The development and use of a new scale, the Epworth sleepiness scale (ESS), is described. This is a simple, self-administered… Expand
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