Narcolepsy

Known as: excessive uncontrollable daytime sleepiness, Gelineaus Syndrome, Narcolepsy NOS 
A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1936-2017
010020019362016

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33 relations
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Broader (3)

CNS disorderDyssomniasnervous system disorder

Narrower (1)

Narcolepsy-Cataplexy Syndrome

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Narcolepsy
CNS disorder
nervous system disorder
Microbiological
Methamphetamine
Amphetamine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice Molecular Genetic Dissection of Non-REM and REM Sleep Regulatory Processes
Narcolepsy-cataplexy, a neurological disorder associated with the absence of hypothalamic orexin (hypocretin) neuropeptides… (More)
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Highly Cited
2002
Highly Cited
2002
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.
CONTEXT Narcolepsy, a neurological disorder affecting 1 in 2000 individuals, is associated with HLA-DQB1*0602 and low… (More)
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Highly Cited
2001
Highly Cited
2001
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss… (More)
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Highly Cited
2001
Highly Cited
2001
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.
Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly… (More)
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Highly Cited
2000
Highly Cited
2000
Hypocretin (orexin) deficiency in human narcolepsy.
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was… (More)
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Highly Cited
2000
Highly Cited
2000
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In… (More)
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Highly Cited
2000
Highly Cited
2000
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
We explored the role of hypocretins in human narcolepsy through histopathology of six narcolepsy brains and mutation screening of… (More)
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Highly Cited
1999
Highly Cited
1999
Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral hypothalamus and send axons to… (More)
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Highly Cited
1999
Highly Cited
1999
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized by daytime sleepiness, cataplexy, and… (More)
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Highly Cited
1991
Highly Cited
1991
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
The development and use of a new scale, the Epworth sleepiness scale (ESS), is described. This is a simple, self-administered… (More)
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