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NUDT15, ARG139HIS

National Institutes of Health

Papers overview

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2019
2019
A missense variant of the nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) gene (R139C) predisposes Asian patients… 
2019
2019
Azathioprine can induce severe myelosuppression, especially leucopenia, in some susceptible individuals. Genome-wide association… 
2019
2019
BACKGROUND Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian… 
2018
2018
The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on… 
2018
2018
Introduction: Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many… 
2018
2018
6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic… 
Review
2017
Review
2017
Background Thiopurines 6-mercaptopurine (6-MP) is the critical anticancer agent used for childhood acute lymphoblastic leukemia… 
Highly Cited
2016
Highly Cited
2016
Thiopurine‐induced leukopenia is the most common dangerous adverse event in Asians. NUDT15 R139C was recently proposed to be a… 
Highly Cited
2015
Highly Cited
2015
BackgroundNUDT15 R139C (rs116855232) is a recently identified genetic factor responsible for thiopurine-induced leukocytopenia…