NUDT15, ARG139HIS
National Institutes of Health
Papers overview
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A missense variant of the nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) gene (R139C) predisposes Asian patients…
Azathioprine can induce severe myelosuppression, especially leucopenia, in some susceptible individuals. Genome-wide association…
BACKGROUND Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian…
The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on…
Introduction: Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many…
6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic…
Background Thiopurines 6-mercaptopurine (6-MP) is the critical anticancer agent used for childhood acute lymphoblastic leukemia…
Thiopurine‐induced leukopenia is the most common dangerous adverse event in Asians. NUDT15 R139C was recently proposed to be a…
BackgroundNUDT15 R139C (rs116855232) is a recently identified genetic factor responsible for thiopurine-induced leukocytopenia…