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NUDT15, ARG139HIS

National Institutes of Health

Related topics

Related topics

1 relation
THIOPURINES, POOR METABOLISM OF, 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Long‐term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine
A missense variant of the nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) gene (R139C) predisposes Asian patients… Expand
2019
2019
First Case of Azathioprine-Induced Severe Hematotoxicity in a Tunisian Patient With Homozygous TT for NUDT15 rs116855232
Azathioprine can induce severe myelosuppression, especially leucopenia, in some susceptible individuals. Genome-wide association… Expand
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2019
2019
Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients
BACKGROUND Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian… Expand
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2018
2018
Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
Background6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute… Expand
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2018
2018
NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients
The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on… Expand
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2018
2018
NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects
Introduction: Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many… Expand
Review
2017
Review
2017
Adjusting Dosage of Mercaptopurine By NUDT15 Polymorphisms in Childhood Acute Lymphoblastic Leukemia
Background Thiopurines 6-mercaptopurine (6-MP) is the critical anticancer agent used for childhood acute lymphoblastic leukemia… Expand
Highly Cited
2016
Highly Cited
2016
NUDT15 polymorphisms are better than thiopurine S‐methyltransferase as predictor of risk for thiopurine‐induced leukopenia in Chinese patients with Crohn's disease
Thiopurine‐induced leukopenia is the most common dangerous adverse event in Asians. NUDT15 R139C was recently proposed to be a… Expand
2016
2016
メルカプトプリンによる重度の血液毒性をきたした NUDT15 ホモバリアントを有する小児急性リンパ性白血病
Highly Cited
2015
Highly Cited
2015
NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease
BackgroundNUDT15 R139C (rs116855232) is a recently identified genetic factor responsible for thiopurine-induced leukocytopenia… Expand
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