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NUDT15, ARG139HIS

 
National Institutes of Health

Related topics

Related topics

1 relation
THIOPURINES, POOR METABOLISM OF, 2

Papers overview

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2019
2019
First Case of Azathioprine-Induced Severe Hematotoxicity in a Tunisian Patient With Homozygous TT for NUDT15 rs116855232
Azathioprine can induce severe myelosuppression, especially leucopenia, in some susceptible individuals. Genome-wide association… Expand
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Review
2019
Review
2019
Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine.
BACKGROUND AND AIM A missense variant of the nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) gene (R139C… Expand
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2019
2019
Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients
BACKGROUND Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian… Expand
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2018
2018
NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients
The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on… Expand
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2018
2018
Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
Background6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute… Expand
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2018
2018
NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects
Introduction: Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many… Expand
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Review
2017
Review
2017
Adjusting Dosage of Mercaptopurine By NUDT15 Polymorphisms in Childhood Acute Lymphoblastic Leukemia
Background Thiopurines 6-mercaptopurine (6-MP) is the critical anticancer agent used for childhood acute lymphoblastic leukemia… Expand
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Review
2016
Review
2016
NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease.
BACKGROUND Thiopurine-induced leukopenia is the most common dangerous adverse event in Asians. NUDT15 R139C was recently proposed… Expand
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2016
2016
メルカプトプリンによる重度の血液毒性をきたした NUDT15 ホモバリアントを有する小児急性リンパ性白血病
 
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2015
2015
NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease
BackgroundNUDT15 R139C (rs116855232) is a recently identified genetic factor responsible for thiopurine-induced leukocytopenia… Expand
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