NUDT15, ARG139HIS
National Institutes of Health
Papers overview
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A missense variant of the nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) gene (R139C) predisposes Asian patients…
Azathioprine can induce severe myelosuppression, especially leucopenia, in some susceptible individuals. Genome-wide association…
BACKGROUND Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian…
The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on…
Introduction: Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many…
6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic…
BackgroundNUDT15 R139C (rs116855232) is a recently identified genetic factor responsible for thiopurine-induced leukocytopenia…
Background Thiopurines 6-mercaptopurine (6-MP) is the critical anticancer agent used for childhood acute lymphoblastic leukemia…
Thiopurine‐induced leukopenia is the most common dangerous adverse event in Asians. NUDT15 R139C was recently proposed to be a…