NUAK2 gene

Known as: NUAK FAMILY, SNF1-LIKE KINASE, 2, SNF1/AMP activated protein kinase, SNF1/AMPK-RELATED PROTEIN KINASE 
 
National Institutes of Health

Papers overview

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2018
2018
NUAK2 is a critical YAP target in liver cancer
The Hippo-YAP signaling pathway is a critical regulator of proliferation, apoptosis, and cell fate. The main downstream effector… Expand
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2016
2016
miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma.
Despite evidence that the crucial role of NUAK family, SNF1-like kinase, 2 [NUAK2; also known as sucrose non-fermenting 1 (SNF1… Expand
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2015
2015
NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.
The AMPK-related kinase NUAK2 has been implicated in melanoma growth and survival outcomes, but its therapeutic utility has yet… Expand
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2014
2014
Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase
NUAK1 (NUAK family SnF1-like kinase-1) and NUAK2 protein kinases are activated by the LKB1 tumour suppressor and have been… Expand
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2013
2013
The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling.
BACKGROUND & AIMS Hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. The biological and therapeutic… Expand
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2012
2012
Neural tube defects by NUAK1 and NUAK2 double mutation
 
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2011
2011
AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma.
The identification of genes that participate in melanomagenesis should suggest strategies for developing therapeutic modalities… Expand
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2011
2011
An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.
Actin stress fiber assembly and contractility in nonmuscle motile cells requires phosphorylation of myosin regulatory light chain… Expand
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Highly Cited
2010
Highly Cited
2010
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.
The AMPK-related kinases NUAK1 and NUAK2 are activated by the tumor suppressor LKB1. We found that NUAK1 interacts with several… Expand
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Highly Cited
2004
Highly Cited
2004
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding… Expand
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