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NUAK2 gene

Known as: NUAK FAMILY, SNF1-LIKE KINASE, 2, SNF1/AMP activated protein kinase, SNF1/AMPK-RELATED PROTEIN KINASE 
 
National Institutes of Health

Papers overview

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2018
2018
NUAK2 is a critical YAP target in liver cancer
The Hippo-YAP signaling pathway is a critical regulator of proliferation, apoptosis, and cell fate. The main downstream effector… Expand
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Highly Cited
2017
Highly Cited
2017
WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3… Expand
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2014
2014
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases
The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated… Expand
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2013
2013
Association between Phosphorylated AMP-Activated Protein Kinase and MAPK3/1 Expression and Prognosis for Patients with Gastric Cancer
Objectives: Phosphorylated AMP-activated protein kinase (pAMPK) plays a central role in cellular metabolic sensing and energy… Expand
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2013
2013
The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling.
BACKGROUND & AIMS Hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. The biological and therapeutic… Expand
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2011
2011
An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers
Actin stress fiber assembly and contractility in nonmuscle motile cells requires phosphorylation of myosin regulatory light chain… Expand
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2011
2011
AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma
The identification of genes that participate in melanomagenesis should suggest strategies for developing therapeutic modalities… Expand
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Highly Cited
2010
Highly Cited
2010
New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion
The kinase NUAK1, which is linked to tumor invasion, promotes cell detachment by activating cytoskeletal motor proteins. An LKB1… Expand
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2009
2009
Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes
Aims/hypothesisSucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) is involved in cellular stress… Expand
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Highly Cited
2004
Highly Cited
2004
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding… Expand
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