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NUAK1 gene

Known as: NuaK1, ARK5, NUAK family kinase 1 
This gene plays a role in DNA damage response, apoptosis inhibition, cell adhesion, cellular senescence, and cell proliferation.
National Institutes of Health

Related topics

Related topics

7 relations
Cell AdhesionCell Proliferation Regulatory ProcessNUAK1 protein, humanNUAK1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice
Background: Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not in adult mice. This… 
Highly Cited
2018
Highly Cited
2018
A Deep Learning Approach for Predicting Antidepressant Response in Major Depression Using Clinical and Genetic Biomarkers
In the wake of recent advances in scientific research, personalized medicine using deep learning techniques represents a new… 
Highly Cited
2013
Highly Cited
2013
Exploring the genetic basis of chronic periodontitis: a genome-wide association study
Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden and is a… 
Highly Cited
2013
Highly Cited
2013
Genome-Wide DNA Methylation Analysis Reveals a Potential Mechanism for the Pathogenesis and Development of Uterine Leiomyomas
Background The pathogenesis of uterine leiomyomas, the most common benign tumor in women, remains unclear. Since acquired factors… 
Highly Cited
2013
Highly Cited
2013
High NUAK1 expression correlates with poor prognosis and involved in NSCLC cells migration and invasion
ABSTRACT Novel (nua) kinase family 1 (NUAK1) is a member of the human adenosine monophosphate (AMP)-activated protein kinase… 
Highly Cited
2012
Highly Cited
2012
Deregulated MYC expression induces dependence upon AMPK-related kinase 5
Deregulated expression of the MYC oncoprotein contributes to the genesis of many human tumours, yet strategies to exploit this… 
Highly Cited
2011
Highly Cited
2011
A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation
It has been suggested that adenosine monophosphate-activated protein kinase (AMPK) and 12 AMPK-related kinases (ARK), including… 
Highly Cited
2010
Highly Cited
2010
New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion
The kinase NUAK1, which is linked to tumor invasion, promotes cell detachment by activating cytoskeletal motor proteins. An LKB1… 
Review
2009
Review
2009
The regulation and function of mammalian AMPK‐related kinases
AMP‐activated protein kinase (AMPK) is a key regulator of cellular and whole‐body energy homeostasis. Recently, 12 AMPK‐related… 
Highly Cited
2005
Highly Cited
2005
ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma
ARK5, AMP-activated protein kinase (AMPK)-related protein kinase mediating Akt signals, is closely involved in tumor progression… 
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