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NSC59984

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 3950: Small molecule NSC59984 synergizes with ROS-generating agents to induce cell death via reduced GSH in cancer cells
NSC59984 is a small molecule with a duel capability to induce mutant p53 degradation and restore p53 pathway signaling in cancer… 
2017
2017
Abstract 2156: NSC59984 induces mutant p53 degradation via activating ERK2 pathway-MDM2 axis
Mutant p53 protein is highly expressed in most cancer cells due to its protein stabilization. Mutant p53 loses wild-type p53… 
2017
2017
Abstract 2155: Small molecule NSC59984 suppresses cancer cell growth under hypoxia
Hypoxia is one of the main features of solid tumors, contributes to drug resistance and is associated with poor prognosis. We… 
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