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NS6180

 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma
Background The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such… Expand
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2017
2017
Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.
The intermediate-conductance Ca2+-activated K+ channel (KCa3.1) constitutes an attractive pharmacological target for… Expand
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2017
2017
JMV5656, A Novel Derivative of TLQP-21, Triggers the Activation of a Calcium-Dependent Potassium Outward Current in Microglial Cells
TLQP-21 (TLQPPASSRRRHFHHALPPAR) is a multifunctional peptide that is involved in the control of physiological functions… Expand
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2017
2017
Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa 3 . 1 Channel Pore s
The intermediate-conductanceCa-activatedKchannel (KCa3.1) constitutes an attractive pharmacological target for immunosuppression… Expand
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2016
2016
Quantification of the functional expression of the Ca2+ -activated K+ channel KCa 3.1 on microglia from adult human neocortical tissue.
The KCa 3.1 channel (KCNN4) is an important modulator of microglia responses in rodents, but no information exists on functional… Expand
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2013
2013
NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.
BACKGROUND AND PURPOSE The K(Ca) 3.1 channel is a potential target for therapy of immune disease. We identified a compound from a… Expand
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2013
2013
Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes
Natural killer (NK) cells are large granular lymphocytes that participate in both innate and adaptive immune responses against… Expand
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2013
2013
A high-throughput screening campaign for detection of ca(2+)-activated k(+) channel activators and inhibitors using a fluorometric imaging plate reader-based tl(+)-influx assay.
The intermediate-conductance Ca(2+)-activated K(+) channel (KCa3.1) has been proposed to play many physiological roles, and… Expand
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2013
2013
KCa 3.1 in inflammatory bowel disease
 
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2013
2013
Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators.
The intermediate-conductance Ca(2+)-activated K(+) channel KCa3.1 (also known as KCNN4, IK1, or the Gárdos channel) plays an… Expand
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