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NS6180

 

Topic mentions per year

Topic mentions per year

2013-2016
02420132016

Papers overview

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2017
2017
Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.
The intermediate-conductance Ca2+-activated K+ channel (KCa3.1) constitutes an attractive pharmacological target for… (More)
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2017
2017
JMV5656, A Novel Derivative of TLQP-21, Triggers the Activation of a Calcium-Dependent Potassium Outward Current in Microglial Cells
TLQP-21 (TLQPPASSRRRHFHHALPPAR) is a multifunctional peptide that is involved in the control of physiological functions… (More)
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Review
2017
Review
2017
KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma.
The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B… (More)
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2016
2016
Quantification of the functional expression of the Ca2+ -activated K+ channel KCa 3.1 on microglia from adult human neocortical tissue.
The KCa 3.1 channel (KCNN4) is an important modulator of microglia responses in rodents, but no information exists on functional… (More)
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2013
2013
NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.
BACKGROUND AND PURPOSE The K(Ca) 3.1 channel is a potential target for therapy of immune disease. We identified a compound from a… (More)
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2013
2013
Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes
Natural killer (NK) cells are large granular lymphocytes that participate in both innate and adaptive immune responses against… (More)
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2013
2013
Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators.
The intermediate-conductance Ca(2+)-activated K(+) channel KCa3.1 (also known as KCNN4, IK1, or the Gárdos channel) plays an… (More)
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2013
2013
A high-throughput screening campaign for detection of ca(2+)-activated k(+) channel activators and inhibitors using a fluorometric imaging plate reader-based tl(+)-influx assay.
The intermediate-conductance Ca(2+)-activated K(+) channel (KCa3.1) has been proposed to play many physiological roles, and… (More)
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