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NS 21

Known as: NS-21 
National Institutes of Health

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temiverine

Papers overview

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2019
2019
Molecular docking study of active diazenyl scaffolds as inhibitors of essential targets towards antimicrobial drug discovery.
BACKGROUND The diazenyl compounds (-N=N- linkage) have been reported to have antimicrobial activity. In modern drug discovery… 
2019
2019
Synthesis and evaluation of novel naphthol diazenyl scaffold based Schiff bases as potential antimicrobial and cytotoxic agents against human colorectal carcinoma cell line (HT-29)
BackgroundIn search of new antimicrobial and cytotoxic agents, a series of new naphthol diazenyl scaffold based Schiff bases (NS1… 
1999
1999
Cytochrome P450 isoforms responsible for the N-deethylation and cyclohexane-hydroxylation of NS-21.
1. Cytochrome P450 (P450) isoforms responsible for the N-deethylation and cyclohexane-hydroxylation of (+/-)-4-diethylamino-1,1… 
1998
1998
Comparison of the effects of NS-21 and terodiline on the QTc interval in dogs.
1997
1997
Effect of NS‐21, an Anticholinergic Drug with Calcium Antagonistic Activity, on Lower Urinary Tract Function in a Rat Model of Urinary Frequency
Background: NS‐21 is under development for the treatment of urinary frequency and urinary incontinence. The purpose of this study… 
1997
1997
Cardiac electrophysiological actions of NS-21 and its active metabolite, RCC-36, compared with terodiline
Terodiline, an anticholinergic drug with a Ca2+ blocking action, is thought to be associated with torsade de pointes, a serious… 
1997
1997
Two-year dietary carcinogenicity study of (+/-)-4-diethylamino-1, 1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary…
The oncogenic potential of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate… 
1997
1997
Seventy-eight-week dietary carcinogenicity study of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for…
The oncogenic potential of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate… 
1997
1997
Inhibitory effects of NS-21, a novel drug for urinary incontinence, and its active metabolite, RCC-36, on L-type calcium currents in isolated guinea pig detrusor smooth muscle cells
The inhibitory effects of NS-21, a newly developed drug for the treatment of urinary frequency and urinary incontinence, and its… 
1997
1997
Anticholinergic and calcium antagonistic activities of NS-21 contribute to the inhibition of rat urinary bladder contractions.
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