NOVA1 protein, human

Known as: Onconeural Ventral Antigen-1, NOVA1, Ri Antigen 
RNA-binding protein Nova-1 (510 aa, ~52 kDa) is encoded by the human NOVA1 gene. This protein is involved in sequence-specific RNA binding.
National Institutes of Health

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Breast CarcinomaCell NucleusCell SurvivalHomo sapiens
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RNA-Binding Proteins

Papers overview

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2015
2015
MicroRNA-339, an epigenetic modulating target is involved in human gastric carcinogenesis through targeting NOVA1.
The role of miR-339 in human gastric cancer (GC) remains unclear. Here, we found that miR-339 is remarkably decreased in primary… (More)
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2014
2014
MiR-181b-5p Downregulates NOVA1 to Suppress Proliferation, Migration and Invasion and Promote Apoptosis in Astrocytoma
MicroRNAs (miRNAs) are small, short noncoding RNAs that modulate the expression of numerous genes by targeting their mRNA… (More)
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2014
2014
Nova1 is a master regulator of alternative splicing in pancreatic beta cells
Alternative splicing (AS) is a fundamental mechanism for the regulation of gene expression. It affects more than 90% of human… (More)
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Highly Cited
2012
Highly Cited
2012
The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by… (More)
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2012
2012
Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1.
The structural complexity of the vertebrate brain is mirrored by its unparalleled transcriptome complexity. In particular, two… (More)
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2008
2008
Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV.
Alternative splicing of pre-mRNAs plays an important role in generating biological and functional diversity. Neuro-oncological… (More)
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2002
2002
Role of dimerization in KH/RNA complexes: the example of Nova KH3.
The K homology module, one of the most common RNA-binding motifs, is present in multiple copies in both prokaryotic and… (More)
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Highly Cited
1998
Highly Cited
1998
The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia.
Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder thought to be mediated by an autoimmune attack against… (More)
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Highly Cited
1997
Highly Cited
1997
The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.
Nova-1, an autoantigen in paraneoplastic opsoclonus myoclonus ataxia (POMA), a disorder associated with breast cancer and motor… (More)
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Highly Cited
1996
Highly Cited
1996
The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies.
Nova-1, a protein expressed in tumors and neurons, is a target antigen in a human paraneoplastic motor disorder [paraneoplastic… (More)
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