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NOVA1 protein, human
Known as:
Onconeural Ventral Antigen-1
, NOVA1
, Ri Antigen
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RNA-binding protein Nova-1 (510 aa, ~52 kDa) is encoded by the human NOVA1 gene. This protein is involved in sequence-specific RNA binding.
National Institutes of Health
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Related topics
Related topics
15 relations
Breast Carcinoma
Cell Nucleus
Cell Survival
Homo sapiens
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Broader (1)
RNA-Binding Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
A. Ludlow
,
Mandy S. Wong
,
+10 authors
J. Shay
Nature Communications
2018
Corpus ID: 51928682
Alternative splicing is dysregulated in cancer and the reactivation of telomerase involves the splicing of TERT transcripts to…
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Highly Cited
2014
Highly Cited
2014
MiR-181b-5p Downregulates NOVA1 to Suppress Proliferation, Migration and Invasion and Promote Apoptosis in Astrocytoma
F. Zhi
,
Qiang Wang
,
+6 authors
Yilin Yang
PLoS ONE
2014
Corpus ID: 14771717
MicroRNAs (miRNAs) are small, short noncoding RNAs that modulate the expression of numerous genes by targeting their mRNA…
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Highly Cited
2014
Highly Cited
2014
Nova1 is a master regulator of alternative splicing in pancreatic beta cells
O. Villate
,
Jean-Valéry Turatsinze
,
+11 authors
D. Eizirik
Nucleic Acids Research
2014
Corpus ID: 16723184
Alternative splicing (AS) is a fundamental mechanism for the regulation of gene expression. It affects more than 90% of human…
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Highly Cited
2012
Highly Cited
2012
The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
D. Eizirik
,
M. Sammeth
,
+15 authors
M. Cnop
PLoS Genetics
2012
Corpus ID: 12945647
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by…
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Highly Cited
2008
Highly Cited
2008
Post-transcriptional Regulation of Neuro-oncological Ventral Antigen 1 by the Neuronal RNA-binding Proteins ELAV*
A. Ratti
,
C. Fallini
,
+4 authors
V. Silani
Journal of Biological Chemistry
2008
Corpus ID: 29706997
Alternative splicing of pre-mRNAs plays an important role in generating biological and functional diversity. Neuro-oncological…
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Highly Cited
2007
Highly Cited
2007
Discovery and Analysis of Evolutionarily Conserved Intronic Splicing Regulatory Elements
Gene W. Yeo
,
E. V. Nostrand
,
T. Liang
PLoS Genetics
2007
Corpus ID: 86274333
Knowledge of the functional cis-regulatory elements that regulate constitutive and alternative pre-mRNA splicing is fundamental…
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2007
2007
Correction: Discovery and Analysis of Evolutionarily Conserved Intronic Splicing Regulatory Elements
Gene W. Yeo
,
E. V. Nostrand
,
T. Liang
PLoS Genetics
2007
Corpus ID: 11886014
Knowledge of the functional cis-regulatory elements that regulate constitutive and alternative pre-mRNA splicing is fundamental…
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Highly Cited
1998
Highly Cited
1998
The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia.
Y. Yang
,
G. Yin
,
R. Darnell
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 24782601
Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder thought to be mediated by an autoimmune attack against…
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Highly Cited
1997
Highly Cited
1997
The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo
R. Buckanovich
,
R. Darnell
Molecular and Cellular Biology
1997
Corpus ID: 10430540
Nova-1, an autoantigen in paraneoplastic opsoclonus myoclonus ataxia (POMA), a disorder associated with breast cancer and motor…
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Highly Cited
1996
Highly Cited
1996
The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies
RJ Buckanovich
,
Yy Yang
,
RB Darnell
Journal of Neuroscience
1996
Corpus ID: 37116425
Nova-1, a protein expressed in tumors and neurons, is a target antigen in a human paraneoplastic motor disorder [paraneoplastic…
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