Skip to search formSkip to main contentSkip to account menu

NOTUM gene

Known as: NOTUM, [Wnt protein] O-palmitoleoyl-L-serine hydrolase, NOTUM, DROSOPHILA, HOMOLOG OF 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM
Progenitor cells are crucial in controlling organ morphogenesis. Tooth development is a well‐established model for investigating… 
2019
2019
NOTUM inhibition increases endocortical bone formation and bone strength
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies… 
Review
2019
Review
2019
Modulating Wnt signaling at the root: Porcupine and Wnt acylation.
2012
2012
A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway
Multiple developmental processes require tightly controlled Wnt signaling, and its misregulation leads to congenital… 
2012
2012
Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling
During development, secreted morphogens, such as Hedgehog (Hh), control cell fate and proliferation. Precise sensing of morphogen… 
Highly Cited
2011
Highly Cited
2011
Steep Differences in Wingless Signaling Trigger Myc-Independent Competitive Cell Interactions
Highly Cited
2008
Highly Cited
2008
Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface.
Glypicans are heparan sulfate proteoglycans that are attached to the cell surface by a GPI (glycosylphosphatidylinositol)anchor… 
Highly Cited
2005
Highly Cited
2005
Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc
Drosophila Wingless (Wg) is the founding member of the Wnt family of secreted proteins. During the wing development, Wg acts as a… 
Highly Cited
2002
Highly Cited
2002
HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.
Highly Cited
1996
Highly Cited
1996
iroquois: a prepattern gene that controls the formation of bristles on the thorax ofDrosophila
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)