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NN1731

National Institutes of Health

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factor VII

Papers overview

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Review
2012
Review
2012
Hemostatic properties of the FVIIa analog NN1731.
2011
2011
Clearance of rFVIIa and NN1731 after intravenous administration to Beagle dogs.
2011
2011
Factor VIII activation by factor VIIa analog (V158D/E296V/M298Q) in tissue factor-independent mechanisms
Summary Factor (F)VIIa with tissue factor (TF) is a primary trigger of blood coagulation. The recombinant (r)FVIIa analog, NN1731… 
2010
2010
rFVIIa and NN1731 reduce bleeding in hydroxyethyl starch hemodiluted rabbits.
BACKGROUND Colloid plasma expanders are used to maintain blood pressure and ensure tissue perfusion during hypovolemia, e.g… 
2010
2010
Factor VIIa analog has marked effects on platelet function and clot kinetics in blood from patients with hemophilia A
To evaluate the hemostatic effects of NN1731 and rFVIIa, an ex-vivo study in hemophilia patients used the Hemodyne Hemostasis… 
2010
2010
Characterizing the Effects of NN1731 and rFVIIa In Severe Hemophilia Patients with a Poor Laboratory Response to In Vivo Dosing of rFVIIa 90 μ g/Kg
Abstract 4414 Introduction: A rFVIIa analogue (NN1731) with increased prothrombinase activity on the activated platelet surface… 
Highly Cited
2007
Highly Cited
2007
Factor VIIa analogue (V158D/E296V/M298Q‐FVIIa) normalises clot formation in whole blood from patients with severe haemophilia A
This study evaluated and compared the haemostatic potential of a recombinant factor VIIa (rFVIIa) analogue (V158D/E296V/M298Q… 
2007
2007
Single Dose Administration of rFVIIa and NN1731 in Two Hemophilia A Dogs.
Introduction: The objective of this pilot study was to evaluate and compare the pharmacokinetic and pharmacodynamic (PK/PD… 
2006
2006
Safety Aspects of NN1731, a New Variant of Recombinant Factor VIIa with Increased Intrinsic Activity, in a Venous Stasis Model in Rabbits.
Variants of recombinant factor VIIa (rFVIIa) with enhanced enzymatic activity have recently been developed. Some variants… 
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