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NN1731

National Institutes of Health

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factor VII

Papers overview

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2011
2011
Clearance of rFVIIa and NN1731 after intravenous administration to Beagle dogs.
2011
2011
Factor VIII activation by factor VIIa analog (V158D/E296V/M298Q) in tissue factor-independent mechanisms
Summary Factor (F)VIIa with tissue factor (TF) is a primary trigger of blood coagulation. The recombinant (r)FVIIa analog, NN1731… 
2010
2010
rFVIIa and NN1731 reduce bleeding in hydroxyethyl starch hemodiluted rabbits.
BACKGROUND Colloid plasma expanders are used to maintain blood pressure and ensure tissue perfusion during hypovolemia, e.g… 
2010
2010
Factor VIIa analog has marked effects on platelet function and clot kinetics in blood from patients with hemophilia A
To evaluate the hemostatic effects of NN1731 and rFVIIa, an ex-vivo study in hemophilia patients used the Hemodyne Hemostasis… 
Highly Cited
2009
Highly Cited
2009
Evaluation of the safety and pharmacokinetics of a fast‐acting recombinant FVIIa analogue, NN1731, in healthy male subjects
Summary.  Background: NN1731 is a recombinant activated factor VII (rFVIIa) analog with enhanced activity. Objectives: This… 
2009
2009
rFVIIa and a new enhanced rFVIIa‐analogue, NN1731, reduce bleeding in clopidogrel‐treated and in thrombocytopenic rats
Summary.  Background: The pharmacological effect of rFVIIa occurs at the surface of activated platelets by enhancing thrombin… 
2007
2007
Effect of recombinant factor VIIa variant (NN1731) on platelet function, clot structure and force onset time in whole blood from healthy volunteers and haemophilia patients
Summary.  NN1731 is a novel variant of recombinant factor VIIa (rFVIIa) that binds to activated platelets, but has greater… 
Highly Cited
2007
Highly Cited
2007
Factor VIIa analogue (V158D/E296V/M298Q‐FVIIa) normalises clot formation in whole blood from patients with severe haemophilia A
This study evaluated and compared the haemostatic potential of a recombinant factor VIIa (rFVIIa) analogue (V158D/E296V/M298Q… 
2007
2007
Single Dose Administration of rFVIIa and NN1731 in Two Hemophilia A Dogs.
Introduction: The objective of this pilot study was to evaluate and compare the pharmacokinetic and pharmacodynamic (PK/PD… 
2006
2006
Safety Aspects of NN1731, a New Variant of Recombinant Factor VIIa with Increased Intrinsic Activity, in a Venous Stasis Model in Rabbits.
Variants of recombinant factor VIIa (rFVIIa) with enhanced enzymatic activity have recently been developed. Some variants… 
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