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NME1 wt Allele

Known as: Nucleoside Diphosphate Kinase-A Gene, NM23 Gene, NM23H1 
Human NME1 wild-type allele is located in the vicinity of 17q21.3 and is approximately 9 kb in length. This allele, which encodes nucleoside… 
National Institutes of Health

Related topics

Related topics

11 relations
17q21.3Cell ProliferationHomo sapiensNeuroblastoma

Broader (1)

NME1 gene

Papers overview

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Highly Cited
2007
Highly Cited
2007
Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.
Nm23-H1 transcriptionally down-regulates expression of the lysophosphatidic acid receptor EDG2 and this down-regulation is… 
Highly Cited
2005
Highly Cited
2005
Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer.
BACKGROUND Reestablishment of metastasis suppressor gene expression may constitute a therapeutic strategy for high-risk breast… 
Highly Cited
2004
Highly Cited
2004
The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines
We have recently characterized a human bladder cancer cell line T24 and a more aggressive lineage related variant of it, T24T. To… 
Highly Cited
2001
Highly Cited
2001
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1
The putative tumor metastasis suppressor nm23H1 was originally identified in murine melanomas by subtraction cloning. It displays… 
Highly Cited
2001
Highly Cited
2001
Epstein-Barr virus nuclear protein EBNA-3C interacts with the human metastatic suppressor Nm23-H1: A molecular link to cancer metastasis
Epstein-Barr virus (EBV) is an oncogenic virus associated with a number of human malignancies including Burkitt lymphoma… 
Highly Cited
1993
Highly Cited
1993
Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas.
Reduced expression of nm23 RNAs/proteins has been associated previously with high tumor metastatic potential. In contrast, we… 
Highly Cited
1993
Highly Cited
1993
Inhibition of cell motility after nm23 transfection of human and murine tumor cells.
Abstract nm23 gene expression has been inversely correlated with tumor metastatic potential in certain tumors including melanomas… 
Highly Cited
1991
Highly Cited
1991
Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis.
The nm23 gene was identified in murine melanoma cells, in which its expression is associated with the cells' metastatic potential… 
Highly Cited
1991
Highly Cited
1991
Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival.
Protein levels corresponding to nm23 were determined in normal and neoplastic breast tissues by immunoperoxidase staining. Nm23… 
Highly Cited
1989
Highly Cited
1989
Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential.
Expression of a recently identified murine gene, nm23, has been previously proposed to be inversely correlated to tumor… 
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