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NIK-333

National Institutes of Health

Papers overview

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2015
2015
Abstract 708A: Suppression of glycolysis by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib via AMPK activation
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Aims: Hepatocellular carcinoma (HCC) is the… 
2012
2012
CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit.
Development of an effective low-cost anti-acquired immunodeficiency syndrome (AIDS) drugs is needed for treatment of AIDS… 
2011
2011
Phase I and pharmacokinetic clinical trial of oral administration of the acyclic retinoid NIK‐333
Aim:  NIK‐333 (an acyclic retinoid) has been reported to prevent recurrence of hepatocellular carcinoma (HCC) in patients after… 
2007
2007
An antioxidant effect by acyclic retinoid suppresses liver tumor in mice.
2007
2007
Inhibition of Balb/c 3T3 cell transformation by synthetic acyclic retinoid NIK-333; possible involvement of enhanced gap junctional intercellular communication.
2006
2006
NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-κB signal pathway
Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type I (HTLV-I) and remains incurable. NIK-333, a novel… 
2005
2005
Prevention of Rat Hepatocarcinogenesis by Acyclic Retinoid Is Accompanied by Reduction in Emergence of Both TGF-α-Expressing Oval-Like Cells and Activated Hepatic Stellate Cells
Abstract: We investigated the preventive effects of a synthetic acyclic retinoid, NIK-333, on the early and late events of… 
2004
2004
An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation.
The present study was designed to determine the effects of NIK-333, a synthetic acyclic retinoid, on N-diethylnitrosamine (DEN… 
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