NEUTROPHIL ACTIN DYSFUNCTION

Known as: NAD 
 
National Institutes of Health

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Broader (1)

Leukocyte Disorders

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Highly Cited
2012
Highly Cited
2012
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
Brown adipose tissue (BAT) can disperse stored energy as heat. Promoting BAT-like features in white adipose (WAT) is an… (More)
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Highly Cited
2011
Highly Cited
2011
Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity
BACKGROUND Sirtuins (SIRT1-7) are a family of NAD-dependent deacetylases and/or ADP-ribosyltransferases that are involved in… (More)
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Highly Cited
2010
Highly Cited
2010
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
Silent information regulators are potent NAD(+)-dependent protein deacetylases, which have been shown to regulate gene silencing… (More)
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Highly Cited
2008
Highly Cited
2008
Negative regulation of the deacetylase SIRT1 by DBC1
SIRT1 is an NAD-dependent deacetylase critically involved in stress responses, cellular metabolism and, possibly, ageing. The… (More)
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Highly Cited
2007
Highly Cited
2007
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults.
Increasing lines of evidence show that resveratrol, a polyphenol compound contained in several dietary products, exhibits… (More)
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Review
2006
Review
2006
NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity
Sirtuins are recently discovered NAD+-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins… (More)
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Review
2002
Review
2002
Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells.
Twenty years ago, we first proposed our hypothesis on beta-cell damage and its prevention (the Okamoto model), according to which… (More)
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Highly Cited
2000
Highly Cited
2000
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
Calorie restriction extends life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may… (More)
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Highly Cited
2000
Highly Cited
2000
Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity.
Elevated plasma levels of the sulfur-containing amino acid homocysteine increase the risk for atherosclerosis, stroke, and… (More)
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Highly Cited
1985
Highly Cited
1985
Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.
Deoxyadenosine has been implicated as the toxic metabolite causing profound lymphopenia in immunodeficient children with a… (More)
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