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NEU1 gene

Known as: SIALIDASE, LYSOSOMAL, neuraminidase 1 (lysosomal sialidase), NEURAMINIDASE 1 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis
Abnormal release of exosomes carrying profibrotic signals by myofibroblasts leads to muscle fibrosis in a lysosomal disease… 
Review
2019
Review
2019
Type I sialidosis, a normosomatic lysosomal disease, in the differential diagnosis of late-onset ataxia and myoclonus: An overview.
2018
2018
Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice
Atherosclerosis is a complex disease that involves alterations in lipoprotein metabolism and inflammation. Protein and lipid… 
2018
2018
Neuraminidase 1–mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection
Pseudomonas aeruginosa (Pa) expresses an adhesin, flagellin, that engages the mucin 1 (MUC1) ectodomain (ED) expressed on airway… 
2018
2018
Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure
The extension of sepsis encompassing the preterm newborn’s brain is often overlooked due to technical challenges in this highly… 
2016
2016
Neuraminidase 1 (NEU1) promotes proliferation and migration as a diagnostic and prognostic biomarker of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is among the most malignant cancers worldwide, lacking biomarkers for subtyping and the reliable… 
Highly Cited
2015
Highly Cited
2015
An intrinsic mechanism of secreted protein aging and turnover
Significance In the blood, secreted proteins have different life spans that determine their abundance and function. Measurements… 
2013
2013
Reducing FLI1 Levels in the MRL/lpr Lupus Mouse Model Impacts T Cell Function by Modulating Glycosphingolipid Metabolism
Systemic Lupus erythematosus (SLE) is an autoimmune disease caused, in part, by abnormalities in cells of the immune system… 
2010
2010
Muscle degeneration in neuraminidase 1-deficient mice results from infiltration of the muscle fibers by expanded connective tissue.
2005
2005
Overexpression of MyoD-inducible lysosomal sialidase (neu1) inhibits myogenesis in C2C12 cells.
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