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NEDD8-specific protease activity

Known as: deneddylase activity 
Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates. [GOC:mah]
National Institutes of Health

Papers overview

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2018
2018
The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity
ABSTRACT The COP9 signalosome inhibits the activity of Cullin-RING E3 ubiquitin ligases by removing Nedd8 modifications from… Expand
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2017
2017
Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster.
NEDD8 conjugation of Cullin has an important role in ubiquitin-mediated protein degradation. The COP9 signalosome, of which CSN5… Expand
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2015
2015
Integration of the catalytic subunit activates deneddylase activity in vivo as final step in fungal COP9 signalosome assembly.
The eight-subunit COP9 signalosome (CSN) is conserved from filamentous fungi to humans and functions at the interface between… Expand
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2015
2015
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex
BackgroundCullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the… Expand
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2013
2013
Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome
Deneddylases remove the ubiquitin-like protein Nedd8 from modified proteins. An increased deneddylase activity has been… Expand
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Highly Cited
2013
Highly Cited
2013
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1
The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that resembles the 19S lid of the… Expand
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2013
2013
Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells
The large tegument proteins of herpesviruses contain N-terminal cysteine proteases with potent ubiquitin and NEDD8-specific… Expand
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2012
2012
The Minimal Deneddylase Core of the COP9 Signalosome Excludes the Csn6 MPN− Domain
The COP9 signalosome (CSN) is a eukaryotic protein complex, which regulates a wide range of biological processes mainly through… Expand
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2009
2009
Tips A time-resolved fluorescence resonance energy transfer-based assay for DEN 1 peptidase activity
Neural precursor cell expressed, developmentally down-regulated gene 8 (NEDD8) is a recently discovered ubiquitin-like… Expand
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2007
2007
NEDD8: a new ataxin-3 interactor.
Machado-Joseph disease (MJD/SCA3) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG tract in… Expand
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