NEDD8-specific protease activity

Known as: deneddylase activity 
Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates. [GOC:mah]
National Institutes of Health

Topic mentions per year

Topic mentions per year

2007-2018
01220072018

Papers overview

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2018
2018
The COP9 signalosome inhibits the activity of Cullin-RING E3 ubiquitin ligases by removing Nedd8 modifications from their Cullin… (More)
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2017
2017
NEDD8 conjugation of Cullin has an important role in ubiquitin-mediated protein degradation. The COP9 signalosome, of which CSN5… (More)
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2016
2016
The COP9 signalosome, composed of eight subunits, is implicated in cancer genetics with its deneddylase activity to modulate… (More)
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2015
2015
The eight-subunit COP9 signalosome (CSN) is conserved from filamentous fungi to humans and functions at the interface between… (More)
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2015
2015
Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family… (More)
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2013
2013
The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that resembles the 19S lid of the… (More)
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2013
2013
Deneddylases remove the ubiquitin-like protein Nedd8 from modified proteins. An increased deneddylase activity has been… (More)
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2013
2013
The large tegument proteins of herpesviruses contain N-terminal cysteine proteases with potent ubiquitin and NEDD8-specific… (More)
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2012
2012
The COP9 signalosome (CSN) is a eukaryotic protein complex, which regulates a wide range of biological processes mainly through… (More)
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2007
2007
Machado-Joseph disease (MJD/SCA3) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG tract in… (More)
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