FAQ

NEDD8-specific protease activity

Known as: deneddylase activity 
Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates. [GOC:mah]
National Institutes of Health

Topic mentions per year

Topic mentions per year

2007-2018
01220072018

Papers overview

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2018
2018
The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity.
The COP9 signalosome inhibits the activity of Cullin-RING E3 ubiquitin ligases by removing Nedd8 modifications from their Cullin… (More)
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2017
2017
Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster.
NEDD8 conjugation of Cullin has an important role in ubiquitin-mediated protein degradation. The COP9 signalosome, of which CSN5… (More)
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2016
2016
Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components
The COP9 signalosome, composed of eight subunits, is implicated in cancer genetics with its deneddylase activity to modulate… (More)
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2015
2015
Integration of the catalytic subunit activates deneddylase activity in vivo as final step in fungal COP9 signalosome assembly.
The eight-subunit COP9 signalosome (CSN) is conserved from filamentous fungi to humans and functions at the interface between… (More)
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2015
2015
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex
Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family… (More)
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2013
2013
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.
The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that resembles the 19S lid of the… (More)
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2013
2013
Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome
Deneddylases remove the ubiquitin-like protein Nedd8 from modified proteins. An increased deneddylase activity has been… (More)
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2013
2013
Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells
The large tegument proteins of herpesviruses contain N-terminal cysteine proteases with potent ubiquitin and NEDD8-specific… (More)
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2012
2012
The Minimal Deneddylase Core of the COP9 Signalosome Excludes the Csn6 MPN− Domain
The COP9 signalosome (CSN) is a eukaryotic protein complex, which regulates a wide range of biological processes mainly through… (More)
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2007
2007
NEDD8: a new ataxin-3 interactor.
Machado-Joseph disease (MJD/SCA3) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG tract in… (More)
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