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NEDD4L gene

Known as: NEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, NEDD4L 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Mutations in the HECT domain of NEDD4L lead to AKT/mTOR pathway deregulation and cause periventricular nodular heterotopia
Neurodevelopmental disorders with periventricular nodular heterotopia (PNH) are etiologically heterogeneous, and their genetic… 
Highly Cited
2013
Highly Cited
2013
Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics
Objective: Single-nucleotide polymorphisms (SNPs) in NEDD4L may influence the ability of the NEDD4L protein to reduce epithelial… 
Highly Cited
2013
Highly Cited
2013
NEDD4L Is Downregulated in Colorectal Cancer and Inhibits Canonical WNT Signaling
The NEDD4 family of E3 ubiquitin ligases includes nine members. Each is a modular protein, containing an N-terminal C2 domain for… 
Highly Cited
2006
Highly Cited
2006
The Deubiquitinating Enzyme Ubp2 Modulates Rsp5-dependent Lys63-linked Polyubiquitin Conjugates in Saccharomyces cerevisiae*>
The functions of Lys63-linked polyubiquitin chains are poorly understood, as are the enzymes that specifically generate Lys63… 
Highly Cited
2005
Highly Cited
2005
14-3-3 Proteins Modulate the Expression of Epithelial Na+ Channels by Phosphorylation-dependent Interaction with Nedd4-2 Ubiquitin Ligase*
The ubiquitin E3 protein ligase Nedd4-2 is a physiological regulator of the epithelial sodium channel ENaC, which is essential… 
Highly Cited
2005
Highly Cited
2005
Association of NEDD4L Ubiquitin Ligase With Essential Hypertension
NEDD4L is a ubiquitin ligase that controls cell surface expression of kidney epithelial Na+ channels by ubiquitin-mediated… 
Highly Cited
2002
Highly Cited
2002
Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript
AbstractThe ubiquitin ligase NEDD4L is a candidate gene for essential hypertension on both functional and genetic grounds. By… 
Highly Cited
2001
Highly Cited
2001
The Nedd4-like Protein KIAA0439 Is a Potential Regulator of the Epithelial Sodium Channel*
The amiloride-sensitive epithelial sodium channel (ENaC) plays a critical role in fluid and electrolyte homeostasis and consists… 
Highly Cited
2001
Highly Cited
2001
NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene
The validation of full-length cDNA represents a crucial step in gene identification and subsequent functional analysis. In… 
Highly Cited
2000
Highly Cited
2000
Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases
ABSTRACT The latent membrane protein (LMP) 2A of Epstein-Barr virus (EBV) is implicated in the maintenance of viral latency and… 
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