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In humans, alcohol is consumed for its rewarding and anxiolytic effects. The central nucleus of the amygdala (CeA) is considered… Expand The neuropeptide oxytocin (OT) plays an important role in the regulation of social and anxiety-like behavior. Our previous… Expand Neonatal maternal separation (MS) is a major early life stress that increases the risk of emotional disorders, visceral pain… Expand The exacerbation of musculoskeletal pain by stress in humans is modeled by the musculoskeletal hyperalgesia in rodents following… Expand BACKGROUND & AIMS
Corticotropin-releasing factor receptor-1 (CRF(1)) mediates the stress-induced colonic motor activity. Less is… Expand CRH and 5-hydroxytryptamine (5-HT) are expressed in human colonic enterochromaffin (EC) cells, but their interactions at the… Expand Corticotropin-releasing factor (CRF) receptors have been reported to play a role in tonic colorectal distension (CRD)-induced… Expand Recently characterized selective agonists and developed antagonists for the corticotropin releasing factor (CRF) receptors are… Expand The stress response involves the activation of two corticotropin-releasing factor (CRF) receptor subtypes. We investigated the… Expand Mechanisms of nonpeptide ligand action at family B G protein-coupled receptors are largely unexplored. Here, we evaluated… Expand