NAI-107
National Institutes of Health
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Abstract Objectives To characterize NAI-107 and related lantibiotics for their in vitro activity against Gram-negative pathogens…
Lantibiotics are ribosomally synthesized and post-translationally modified antimicrobial peptides containing thioether rings. In…
The investigation of self-resistance in antibiotic producers is important to understand the emergence of antibiotic resistance in…
ABSTRACT We used the fruit fly Drosophila melanogaster as a cost-effective in vivo model to evaluate the efficacy of novel…
We identified an Actinoallomurus strain producing NAI-107, a chlorinated lantibiotic effective against multidrug-resistant Gram…
Background: NAI-107 is a potent lantibiotic with an unknown mode of action. Results: NAI-107 targets bactoprenol-bound cell…
NAI-107, a lantibiotic produced by Microbispora sp. 107891, shows potent activity against multi-drug-resistant bacterial…
ABSTRACT NAI-107 is a novel lantibiotic compound with potent in vitro activity against Gram-positive bacteria, including…
ABSTRACT NAI-107 is a novel lantibiotic active against Gram-positive bacteria, including methicillin-resistant Staphylococcus…