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NAI-107

 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

microbisporicin

Papers overview

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2017
2017
Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.
Lantibiotics are ribosomally synthesized and post-translationally modified antimicrobial peptides containing thioether rings. In… Expand
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2016
2016
Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis.
Class I lantibiotic dehydratases dehydrate selected Ser/Thr residues of a precursor peptide. Recent studies demonstrated the… Expand
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2016
2016
Distinct mechanisms contribute to immunity in the lantibiotic NAI-107 producer strain Microbispora ATCC PTA-5024.
The investigation of self-resistance in antibiotic producers is important to understand the emergence of antibiotic resistance in… Expand
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2015
2015
Brominated Variant of the Lantibiotic NAI-107 with Enhanced Antibacterial Potency.
We identified an Actinoallomurus strain producing NAI-107, a chlorinated lantibiotic effective against multidrug-resistant Gram… Expand
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2015
2015
In vivo pharmacokinetics and pharmacodynamics of the lantibiotic NAI-107 in a neutropenic murine thigh infection model.
NAI-107 is a novel lantibiotic compound with potent in vitro activity against Gram-positive bacteria, including methicillin… Expand
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Review
2015
Review
2015
Advancing cell wall inhibitors towards clinical applications
Natural products represent a major source of approved drugs and still play an important role in supplying chemical diversity… Expand
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2014
2014
The Lantibiotic NAI-107 Binds to Bactoprenol-bound Cell Wall Precursors and Impairs Membrane Functions*
Background: NAI-107 is a potent lantibiotic with an unknown mode of action. Results: NAI-107 targets bactoprenol-bound cell… Expand
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2014
2014
Characterization of the congeners in the lantibiotic NAI-107 complex.
NAI-107, a lantibiotic produced by Microbispora sp. 107891, shows potent activity against multi-drug-resistant bacterial… Expand
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2012
2012
Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107.
Lantibiotics 97518 and NAI-107, produced by the related genera Planomonospora and Microbispora respectively, are members of a… Expand
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Highly Cited
2011
Highly Cited
2011
Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive pathogens.
NAI-107 is a novel lantibiotic active against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA… Expand
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