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N6AMT1 gene

Known as: N-6 adenine-specific DNA methyltransferase 1 (putative), N6AMT1, N6AMT 
 
National Institutes of Health

Papers overview

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2019
2019
Structural insight into human N6amt1–Trm112 complex functioning as a protein methyltransferase
DNA methylation is an important epigenetic modification in many organisms and can occur on cytosine or adenine. N6-methyladenine… Expand
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2019
2019
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells
Histone lysine methylation is generally performed by SET domain methyltransferases and regulates chromatin structure and gene… Expand
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2019
2019
Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro
Dear Editor, Human MettL3 and MettL14 are two members of the MT-A70 family of S-adenosyl-L-methionine (SAM)dependent… Expand
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2019
2019
The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells
Methylation is a widespread modification occurring in DNA, RNA and proteins. The N6AMT1 (HEMK2) protein has DNA N6-methyladenine… Expand
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Highly Cited
2018
Highly Cited
2018
N6-Methyladenine DNA Modification in the Human Genome.
DNA N6-methyladenine (6mA) modification is the most prevalent DNA modification in prokaryotes, but whether it exists in human… Expand
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2018
2018
Association of N6AMT1 rs2254638 Polymorphism With Clopidogrel Response in Chinese Patients With Coronary Artery Disease
Dual antiplatelet treatment with aspirin and clopidogrel is the standard therapy for patients undergoing percutaneous coronary… Expand
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2017
2017
Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N‐6 adenine‐specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a chilean…
Inter-individual differences in arsenic metabolism have been linked to arsenic-related disease risks. Arsenic (+3… Expand
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2015
2015
Interactive Effects of N 6 AMT 1 and As 3 MT in Arsenic Biomethylation
In humans, arsenic is primarily metabolized by arsenic (þ3 oxidation state) methyltransferase (As3MT) to yield both trivalent and… Expand
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2011
2011
Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 (N6AMT1) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity
Background In humans, inorganic arsenic (iAs) is metabolized to methylated arsenical species in a multistep process mainly… Expand
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2010
2010
Deficiency in a glutamine-specific methyltransferase for release factor causes mouse embryonic lethality.
Biological methylation is a fundamental enzymatic reaction for a variety of substrates in multiple cellular processes. Mammalian… Expand
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