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N-methylnicotinium, (R)-isomer

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-1992
02419841992

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1992
1992
Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary N-methylated nicotine metabolites.
The effects of quaternary N-methylated nicotine derivatives were examined on in vitro uptake of [3H]dopamine ([3H]DA) in rat… (More)
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1988
1988
Inhibition of histamine N-methyltransferase activity in guinea-pig pulmonary alveolar macrophages by nicotine.
Both S-(-)- and R-(+)-nicotine enantiomers are inhibitors of histamine N tau-methylation activity in guinea-pig pulmonary… (More)
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1988
1988
Stereoselectivity in the N'-oxidation of nicotine isomers by flavin-containing monooxygenase.
N'-Oxidation of nicotine isomers by porcine liver flavin-containing monooxygenase shows a clear stereoselectivity in the… (More)
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1988
1988
Enantioselective metabolism during continuous administration of S-(-)- and R-(+)-nicotine isomers to guinea-pigs.
The S-(-)- and R-(+)-nicotine isomers were administered subcutaneously via Alzet osmotic pumps to male Hartley guinea-pigs (n = 5… (More)
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1988
1988
Biotransformation of primary nicotine metabolites: metabolism of R-(+)-[3H-N'-CH3; 14C-N-CH3] N-methylnicotinium acetate--the use of double isotope studies to determine the in-vivo stability of the N…
The in-vivo metabolism of R-(+)-[3H-N'-CH3; 14C-N-CH3]-N-methylnicotinium acetate (NMN) was studied in the guinea-pig to… (More)
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1986
1986
The ability of amine N-methyltransferases from rabbit liver to N-methylate azaheterocycles.
The substrate specificity of two homogeneous amine N-methyltransferases from rabbit liver has been demonstrated to extend to the… (More)
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1985
1985
Biotransformation of primary nicotine metabolites. I. In vivo metabolism of R-(+)-[14C-NCH3]N-methylnicotinium ion in the guinea pig.
The in vivo biotransformation and tissue distribution of the methylated nicotine metabolite R-(+)-[14C-NCH3]N-methylnicotinium… (More)
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1984
1984
Evidence of stereospecificity in the in vivo methylation of [14C](+/-)-nicotine in the guinea pig.
In vivo metabolism of [14C]nicotine to N-methylnicotinium ion in the guinea pig appears to be a stereospecific biotransformation… (More)
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