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Mutate

To change the genetic material of a cell. The changes (mutations) can be harmful, beneficial, or have no effect.
National Institutes of Health

Related topics

Related topics

2 relations
MutationMutation Abnormality

Papers overview

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Highly Cited
2013
Highly Cited
2013
Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness.
Highly Cited
2011
Highly Cited
2011
Channelrhodopsin engineering and exploration of new optogenetic tools
Rhodopsins from microalgae and eubacteria are powerful tools for manipulating the function of neurons and other cells, but these… 
Review
2006
Review
2006
Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures.
Highly Cited
2002
Highly Cited
2002
A novel single molecule analysis of spontaneous and radiation-induced mutation at a mouse tandem repeat locus.
Review
2001
Review
2001
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer.
Gene function in cancer can be disrupted either through genetic alterations, which directly mutate or delete genes, or epigenetic… 
Highly Cited
1999
Highly Cited
1999
regA, a Volvox gene that plays a central role in germ-soma differentiation, encodes a novel regulatory protein.
Volvox has two cell types: mortal somatic cells and immortal germ cells. Here we describe the transposon-tagging, cloning and… 
Highly Cited
1998
Highly Cited
1998
High-resolution mapping of crossovers in human sperm defines a minisatellite-associated recombination hotspot.
Highly Cited
1994
Highly Cited
1994
Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function.
Highly Cited
1992
Highly Cited
1992
A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice.
We have confirmed that the gene trap vector pGT4.5 creates spliced fusion transcripts with endogenous genes and prevents the… 
Highly Cited
1985
Highly Cited
1985
Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.
The principal catalytic factor in the activation of tyrosine by the tyrosyl-tRNA synthetase is found to be improved binding of… 
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