Mustard Prodrug

A mustard compound that gets converted to an active mustard alkylating agent at a tumor site, causing DNA cross-linking. These compounds may be used… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Cancer is considered as one of the most serious health problems today. The discovery of nitrogen mustard as an alkylating agent… Expand
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2010
2010
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Hypoxia occurs in most human tumors and is… Expand
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2006
2006
PURPOSE Antibody-directed enzyme prodrug therapy is a two-stage treatment whereby a tumor-targeted antibody-enzyme complex… Expand
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2006
2006
Purpose: Antibody-directed enzyme prodrug therapy is a two-stage treatment whereby a tumor-targeted antibody-enzyme complex… Expand
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2004
2004
The potential antibody directed prodrug therapy half-mustard prodrug 4-[(2-chloroethyl)(2-ethyl)amino]-phenoxycarbonyl-L-glutamic… Expand
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1996
1996
The gene for the bacterial enzyme carboxypeptidase G2 (CPG2) was expressed internally in mammalian cells. Mammalian-expressed… Expand
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1992
1992
Cephalosporin mustard (CM) was designed as an anticancer prodrug that could be activated in a site-specific manner by monoclonal… Expand
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