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Multiplex Ligation-Dependent Probe Amplification
Known as:
MLPA
, Multiplex Ligation Dependent Probe Amplification
A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a…
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National Institutes of Health
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Related topics
Related topics
2 relations
Clinical Data Interchange Standards Consortium Terminology
Multiplex Polymerase Chain Reaction
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Evidence‐based path to newborn screening for duchenne muscular dystrophy
J. Mendell
,
C. Shilling
,
+16 authors
R. Weiss
Annals of Neurology
2012
Corpus ID: 16844705
Creatine kinase (CK) levels are increased on dried blood spots in newborns related to the birthing process. As a marker for…
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Review
2012
Review
2012
Multiplex Ligation-dependent Probe Amplification (MLPA) in Tumor Diagnostics and Prognostics
Cornelia Hömig‐Hölzel
,
S. Savola
Diagnostic molecular pathology (Print)
2012
Corpus ID: 23981500
The increasing knowledge about genetic alterations and molecular biomarkers in cancer initiation and progression opens new…
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Highly Cited
2010
Highly Cited
2010
Genotypic Profiling of 452 Choroidal Melanomas with Multiplex Ligation-Dependent Probe Amplification
B. Damato
,
J. Dopierala
,
S. Coupland
Clinical Cancer Research
2010
Corpus ID: 596674
Purpose: Metastasis from uveal melanoma occurs almost exclusively with tumors showing chromosome 3 loss. We used multiplex…
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Highly Cited
2009
Highly Cited
2009
Multiplex ligation-dependent probe amplification of uveal melanoma: correlation with metastatic death.
B. Damato
,
J. Dopierala
,
A. Klaasen
,
Marcory C R F Van Dijk
,
J. Sibbring
,
S. Coupland
Investigative Ophthalmology and Visual Science
2009
Corpus ID: 36252894
PURPOSE To evaluate multiplex ligation-dependent probe amplification (MLPA) of uveal melanoma as a predictive tool for metastatic…
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Highly Cited
2009
Highly Cited
2009
Genomic Analysis Using High-Density Single Nucleotide Polymorphism-Based Oligonucleotide Arrays and Multiplex Ligation-Dependent Probe Amplification Provides a Comprehensive Analysis of INI1/SMARCB1…
E. Jackson
,
Angela J. Sievert
,
+7 authors
J. Biegel
Clinical Cancer Research
2009
Corpus ID: 7290742
Purpose: A high-resolution genomic profiling and comprehensive targeted analysis of INI1/SMARCB1 of a large series of pediatric…
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Highly Cited
2006
Highly Cited
2006
Multiplex ligation-dependent probe amplification improves diagnostics in spinal muscular atrophy
E. Arkblad
,
N. Darín
,
+6 authors
M. Nordling
Neuromuscular Disorders
2006
Corpus ID: 41947366
Highly Cited
2005
Highly Cited
2005
Nine unknown rearrangements in 16p13.3 and 11p15.4 causing α- and β-thalassaemia characterised by high resolution multiplex ligation-dependent probe amplification
C. Harteveld
,
A. Voskamp
,
+4 authors
P. Giordano
Journal of Medical Genetics
2005
Corpus ID: 40222849
Background: Approximately 80% of the α- and 10% of the β-thalassaemias are caused by genomic deletions involving the α- and…
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Highly Cited
2004
Highly Cited
2004
Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification
D. Bunyan
,
D M Eccles
,
+8 authors
N C P Cross
British Journal of Cancer
2004
Corpus ID: 7293473
Multiplex ligation-dependent probe amplification (MLPA) is a recently described method for detecting gross deletions or…
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Highly Cited
2004
Highly Cited
2004
Two‐color multiplex ligation‐dependent probe amplification: Detecting genomic rearrangements in hereditary multiple exostoses
S. White
,
G. Vink
,
+5 authors
J. T. Dunnen
Human Mutation
2004
Corpus ID: 22555321
Genomic deletions and duplications play an important role in the etiology of human disease. Versatile tests are required to…
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Highly Cited
2002
Highly Cited
2002
Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification.
J. Schouten
,
C. Mcelgunn
,
Raymond Waaijer
,
D. Zwijnenburg
,
Filip Diepvens
,
G. Pals
Nucleic Acids Research
2002
Corpus ID: 15632803
We describe a new method for relative quantification of 40 different DNA sequences in an easy to perform reaction requiring only…
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