Skip to search formSkip to main contentSkip to account menu

Multiplex Ligation-Dependent Probe Amplification

Known as: MLPA, Multiplex Ligation Dependent Probe Amplification 
A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a… 
National Institutes of Health

Related topics

Related topics

2 relations
Clinical Data Interchange Standards Consortium TerminologyMultiplex Polymerase Chain Reaction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple-negative breast cancer (TNBC): Results from…
1005 Background: We previously showed in participants with TNBC of the neoadjuvant phase II GeparSixto study (NCT01426880) that… 
2011
2011
Multiplex ligation-dependent probe amplification analysis of uveal melanoma with extraocular extension demonstrates heterogeneity of gross chromosomal abnormalities.
PURPOSE To determine whether biopsy of extraocular extension of uveal melanoma (UM) is representative of the intraocular tumor… 
2011
2011
Validation of the Multiplex Ligation-dependent Probe Amplification (MLPA) Technique for the Determination of HER2 Gene Amplification in Breast Cancer
Background Multiplex ligation-dependent probe amplification (MLPA) is a polymerase chain reaction-based assay that can assess… 
2010
2010
Simultaneous detection of trisomies 13, 18, and 21 with multiplex ligation-dependent probe amplification-based real-time PCR.
BACKGROUND Trisomies 13, 18, and 21 account for the majority of chromosomal aneuploidies detected in prenatal diagnosis… 
Highly Cited
2007
Highly Cited
2007
Genetic and epigenetic alterations in the differential diagnosis of malignant melanoma and spitzoid lesion
Background  The histopathological differentiation of malignant melanoma and Spitz naevus often presents diagnostic problems. 
Highly Cited
2007
Highly Cited
2007
Quantification of the methylation status of the PWS/AS imprinted region: comparison of two approaches based on bisulfite sequencing and methylation-sensitive MLPA.
2005
2005
Detection of cryptic subtelomeric chromosome abnormalities and identification of anonymous chromatin using a quantitative multiplex ligation‐dependent probe amplification (MLPA) assay
The need to detect clinically significant segmental aneuploidies beyond the range of light microscopy demands the development of… 
2005
2005
Automatic analysis of multiplex ligation‐dependent probe amplification products (exemplified by a commercial kit for prenatal aneuploidy detection)
For use in routine prenatal diagnostics, we developed software and methods for automatic aneuploidy detection based on a… 
2005
2005
Detection of homozygous and heterozygous SMN deletions of spinal muscular atrophy in a single assay with multiplex ligation-dependent probe amplification.
OBJECTIVE Spinal muscular atrophy(SMA), an autosomal recessive neuromuscular degeneration of the anterior horn cells of the… 
Highly Cited
1978
Highly Cited
1978
An Escherichia coli mutant with an amino acid alteration within the signal sequence of outer membrane prolipoprotein.
Lipoprotein has been purified from an Escherichia coli strain carrying a mutation in the structural gene for murein lipoprotein… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)