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Multiplex Ligation-Dependent Probe Amplification

Known as: MLPA, Multiplex Ligation Dependent Probe Amplification 
A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Next-generation sequencing has revolutionized clinical diagnostic testing. Yet, for a substantial proportion of patients… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE Metastasis from uveal melanoma occurs almost exclusively with tumors showing chromosome 3 loss. We used multiplex… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE To determine intratumor genetic heterogeneity in uveal melanoma (UM) by multiplex ligation-dependent probe amplification… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE To evaluate multiplex ligation-dependent probe amplification (MLPA) of uveal melanoma as a predictive tool for metastatic… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE A high-resolution genomic profiling and comprehensive targeted analysis of INI1/SMARCB1 of a large series of pediatric… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Approximately 80% of the alpha- and 10% of the beta-thalassaemias are caused by genomic deletions involving the alpha… Expand
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Highly Cited
2004
Highly Cited
2004
Multiplex ligation-dependent probe amplification (MLPA) is a recently described method for detecting gross deletions or… Expand
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Highly Cited
2004
Highly Cited
2004
Genomic deletions and duplications play an important role in the etiology of human disease. Versatile tests are required to… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Subtelomeric rearrangements contribute to idiopathic mental retardation and human malformations, sometimes as distinct… Expand
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Highly Cited
2002
Highly Cited
2002
We describe a new method for relative quantification of 40 different DNA sequences in an easy to perform reaction requiring only… Expand
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