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Multiplex Ligation-Dependent Probe Amplification

Known as: MLPA, Multiplex Ligation Dependent Probe Amplification 
A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a… 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Creatine kinase (CK) levels are increased on dried blood spots in newborns related to the birthing process. As a marker for… 
Review
2012
Review
2012
The increasing knowledge about genetic alterations and molecular biomarkers in cancer initiation and progression opens new… 
Highly Cited
2010
Highly Cited
2010
Purpose: Metastasis from uveal melanoma occurs almost exclusively with tumors showing chromosome 3 loss. We used multiplex… 
Highly Cited
2009
Highly Cited
2009
PURPOSE To evaluate multiplex ligation-dependent probe amplification (MLPA) of uveal melanoma as a predictive tool for metastatic… 
Highly Cited
2009
Highly Cited
2009
Purpose: A high-resolution genomic profiling and comprehensive targeted analysis of INI1/SMARCB1 of a large series of pediatric… 
Highly Cited
2005
Highly Cited
2005
Background: Approximately 80% of the α- and 10% of the β-thalassaemias are caused by genomic deletions involving the α- and… 
Highly Cited
2004
Highly Cited
2004
Multiplex ligation-dependent probe amplification (MLPA) is a recently described method for detecting gross deletions or… 
Highly Cited
2004
Highly Cited
2004
Genomic deletions and duplications play an important role in the etiology of human disease. Versatile tests are required to… 
Highly Cited
2002
Highly Cited
2002
We describe a new method for relative quantification of 40 different DNA sequences in an easy to perform reaction requiring only…