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Multiplex Ligation-Dependent Probe Amplification

Known as: MLPA, Multiplex Ligation Dependent Probe Amplification 
A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a… 
National Institutes of Health

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Clinical Data Interchange Standards Consortium TerminologyMultiplex Polymerase Chain Reaction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple-negative breast cancer (TNBC): Results from…
1005 Background: We previously showed in participants with TNBC of the neoadjuvant phase II GeparSixto study (NCT01426880) that… 
2010
2010
Simultaneous detection of trisomies 13, 18, and 21 with multiplex ligation-dependent probe amplification-based real-time PCR.
BACKGROUND Trisomies 13, 18, and 21 account for the majority of chromosomal aneuploidies detected in prenatal diagnosis… 
2008
2008
Gene dosage imbalances in patients with 46,XY gonadal DSD detected by an in‐house‐designed synthetic probe set for multiplex ligation‐dependent probe amplification analysis
The development of a testis requires the proper spatiotemporal expression of the SRY gene and other genes that act in a dosage… 
Highly Cited
2007
Highly Cited
2007
Copy number analysis of survival motor neuron genes by multiplex ligation-dependent probe amplification
Purpose: To determine the copy number of survival motor genes using multiplex ligation-dependent probe amplification.Methods… 
Highly Cited
2007
Highly Cited
2007
Genetic and epigenetic alterations in the differential diagnosis of malignant melanoma and spitzoid lesion
Background  The histopathological differentiation of malignant melanoma and Spitz naevus often presents diagnostic problems. 
Highly Cited
2007
Highly Cited
2007
Quantification of the methylation status of the PWS/AS imprinted region: comparison of two approaches based on bisulfite sequencing and methylation-sensitive MLPA.
2006
2006
Comparison of multiplex ligation dependent probe amplification to immunohistochemistry for assessing HER-2/neu amplification in invasive breast cancer
The HER-2/neu transmembrane tyrosine kinase receptor is both a prognostic marker and a therapeutic target for breast cancer… 
2005
2005
Detection of cryptic subtelomeric chromosome abnormalities and identification of anonymous chromatin using a quantitative multiplex ligation‐dependent probe amplification (MLPA) assay
The need to detect clinically significant segmental aneuploidies beyond the range of light microscopy demands the development of… 
2005
2005
Automatic analysis of multiplex ligation‐dependent probe amplification products (exemplified by a commercial kit for prenatal aneuploidy detection)
For use in routine prenatal diagnostics, we developed software and methods for automatic aneuploidy detection based on a… 
Highly Cited
1978
Highly Cited
1978
An Escherichia coli mutant with an amino acid alteration within the signal sequence of outer membrane prolipoprotein.
Lipoprotein has been purified from an Escherichia coli strain carrying a mutation in the structural gene for murein lipoprotein… 
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