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Multicenter Trials

Known as: Trials, Multicentre, Trial, Multicenter, Multicentre Trial 
National Institutes of Health

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Multicenter Studies as Topic
Multicenter Study

Papers overview

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Highly Cited
2019
Highly Cited
2019
Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes.
BACKGROUND Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes… 
Highly Cited
2009
Highly Cited
2009
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial.
RATIONALE Sustained sepsis-associated immunosuppression is associated with uncontrolled infection, multiple organ dysfunction… 
Highly Cited
2007
Highly Cited
2007
Defunctioning Stoma Reduces Symptomatic Anastomotic Leakage After Low Anterior Resection of the Rectum for Cancer: A Randomized Multicenter Trial
Objective:The aim of this randomized multicenter trial was to assess the rate of symptomatic anastomotic leakage in patients… 
Highly Cited
2000
Highly Cited
2000
A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease.
BACKGROUND & AIMS Clinical experience suggests that 6-mercaptopurine (6-MP) is effective therapy for children with active steroid… 
Highly Cited
2000
Highly Cited
2000
Effectiveness of team-managed home-based primary care: a randomized multicenter trial.
CONTEXT Although home-based health care has grown over the past decade, its effectiveness remains controversial. A prior trial of… 
Review
1999
Review
1999
Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: a multicenter trial. Multicenter Selective Lymphadenectomy Trial Group.
OBJECTIVE To evaluate the multicenter application of intraoperative lymphatic mapping, sentinel lymphadenectomy, and selective… 
Highly Cited
1997
Highly Cited
1997
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis…
OBJECTIVE To determine the therapeutic efficacy and safety of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) in… 
Highly Cited
1994
Highly Cited
1994
Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86.
In trial ALL-BFM 86, the largest multicenter trial of the Berlin-Frankfurt-Münster (BFM) study group for childhood acute… 
Highly Cited
1994
Highly Cited
1994
Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612…
PURPOSE We designed a prospective randomized trial to compare vinorelbine and cisplatin (NVB-P) with vindesine and cisplatin (VDS… 
Highly Cited
1989
Highly Cited
1989
Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial.
STUDY OBJECTIVE To determine the efficacy of a corticosteroid in reducing the short-term mortality of patients with severe… 
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