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Mucoadhesive Paclitaxel Formulation

Known as: DHP107 
An orally available, mucoadhesive lipid preparation consisting of paclitaxel, a compound extracted from the Pacific yew tree Taxus brevifolia, in a… 
National Institutes of Health

Related topics

Related topics

2 relations
Microtubule ProcessNCIt Antineoplastic Agent Terminology

Papers overview

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2020
2020
Abstract OT1-05-02: A phase II study to evaluate the efficacy, safety and pharmacokinetics of DHP107 (Liporaxel®, oral paclitaxel) compared to IV paclitaxel in patients with recurrent or metastatic…
Background: Paclitaxel is a commonly used anticancer drug worldwide for various cancers including breast cancer. DHP107 is a… 
2020
2020
[OPTIMAL 3] A phase III trial to evaluate the efficacy and safety of DHP107 (Liporaxel, oral paclitaxel) compared to Taxol (IV paclitaxel) as first line therapy in patients with recurrent or…
TPS1106Background: Paclitaxel is a microtubule-stabilizing drug used for various cancers including breast cancer (BC) and gastric… 
2016
2016
Efficacy and safety findings from DREAM: A phase III study of DHP107 (oral paclitaxel) vs IV paclitaxel in patients with gastric cancer after failure of first-line chemotherapy.
4016Background: Paclitaxel is currently only available as an IV formulation. DHP107 is a novel oral formulation composed of lipid… 
2016
2016
Formulation and evaluation of mucoadhesive microcapsules of aceclofenac
Aceclofenac loaded microcapsules with a coat consisting of sodium alginate and mucoadhesive polymer of different grades of… 
2015
2015
A phase III study to compare efficacy and safety of DHP107 (oral paclitaxel) versus IV paclitaxel in patients with metastatic or recurrent gastric cancer after failure of first-line chemotherapy…
TPS4138 Background: Paclitaxel is an antineoplastic agent widely used for treating cancer patients. However, only IV paclitaxel… 
2014
2014
Metronomic oral paclitaxel shows anti-tumor effects in an orthotopic mouse model of ovarian cancer
Objective The purpose of this study was to compare the in vivo anti-tumor efficacy of a mucoadhesive, lipid-based, oral… 
2014
2014
A phase I/II study of DHP107, a novel oral paclitaxel formulation, in patients with advanced solid tumors (phase I) and gastric cancer (phase II).
101 Background: Paclitaxel has been proven to be effective and widely used in various types of cancers. DHP107 is a novel oral… 
2013
2013
Absorption profiles of an oral paclitaxel formulation , DHP 107 with variable dosing intervals in mice
SUMMARY The absorption of paclitaxel was evaluated after bid dosing of an oral paclitaxel formulation, DHP107 in mice. DHP107 was… 
2011
2011
Abstract 2539: Antitumor effects of oral paclitaxel DHP107 on gastric cancer xenografts
Oral paclitaxel DHP107 (Daehwa, Seoul Korea), an antineoplastic agent, is effectively absorbed through the gastrointestinal tract… 
2009
2009
Microemulsion based intranasal delivery system for treatment of insomnia
The aim of this investigation was to prepare and characterize microemulsions/mucoadhesive microemulsions of Diazepam (D… 
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