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Mucoadhesive Paclitaxel Formulation

Known as: DHP107 
An orally available, mucoadhesive lipid preparation consisting of paclitaxel, a compound extracted from the Pacific yew tree Taxus brevifolia, in a… 
National Institutes of Health

Related topics

Related topics

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Microtubule ProcessNCIt Antineoplastic Agent Terminology

Papers overview

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2019
2019
Subacute toxicity and toxicokinetics study of DHP107, an oral paclitaxel formulation with once‐weekly dosing in mice
2019
2019
DHP107, a novel oral paclitaxel formulation induces less peripheral neuropathic pain and pain-related molecular alteration than intravenous paclitaxel preparation in rat
2016
2016
Efficacy and safety findings from DREAM: A phase III study of DHP107 (oral paclitaxel) vs IV paclitaxel in patients with gastric cancer after failure of first-line chemotherapy.
4016Background: Paclitaxel is currently only available as an IV formulation. DHP107 is a novel oral formulation composed of lipid… 
2016
2016
Formulation and evaluation of mucoadhesive microcapsules of aceclofenac
Aceclofenac loaded microcapsules with a coat consisting of sodium alginate and mucoadhesive polymer of different grades of… 
2015
2015
A phase III study to compare efficacy and safety of DHP107 (oral paclitaxel) versus IV paclitaxel in patients with metastatic or recurrent gastric cancer after failure of first-line chemotherapy…
TPS4138 Background: Paclitaxel is an antineoplastic agent widely used for treating cancer patients. However, only IV paclitaxel… 
2014
2014
Metronomic oral paclitaxel shows anti-tumor effects in an orthotopic mouse model of ovarian cancer
Objective The purpose of this study was to compare the in vivo anti-tumor efficacy of a mucoadhesive, lipid-based, oral… 
2014
2014
A phase I/II study of DHP107, a novel oral paclitaxel formulation, in patients with advanced solid tumors (phase I) and gastric cancer (phase II).
101 Background: Paclitaxel has been proven to be effective and widely used in various types of cancers. DHP107 is a novel oral… 
2013
2013
A phase I study of DHP107, a mucoadhesive lipid form of oral paclitaxel, in patients with advanced solid tumors: Crossover comparisons with intravenous paclitaxel
SummaryPurpose This study investigated the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacokinetic (PK… 
2011
2011
Abstract 2539: Antitumor effects of oral paclitaxel DHP107 on gastric cancer xenografts
Oral paclitaxel DHP107 (Daehwa, Seoul Korea), an antineoplastic agent, is effectively absorbed through the gastrointestinal tract… 
2009
2009
Microemulsion based intranasal delivery system for treatment of insomnia
The aim of this investigation was to prepare and characterize microemulsions/mucoadhesive microemulsions of Diazepam (D… 
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