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Monoclonal Antibody MGA271

Known as: MGA271 
An Fc-domain optimized, humanized monoclonal antibody directed against cancer stem cells (CSCs), with potential immunomodulating and antineoplastic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2015
01220122015

Related topics

Related topics

1 relation
antigen binding

Related mentions per year

Related mentions per year

1957-2018
1960198020002020
Monoclonal Antibody MGA271
antigen binding

Papers overview

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2015
2015
A Phase I, open-label, dose escalation study of MGA271 in combination with pembrolizumab in patients with B7-H3-expressing melanoma, squamous cell cancer of the head and neck, or squamous cell non…
Background MGA271 is an Fc optimized humanized IgG1 monoclonal antibody that binds to B7-H3 (CD276), a member of the B7 family… (More)
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2015
2015
A Phase I, open-label, dose escalation study of MGA271 in combination with ipilimumab in patients with B7-H3-expressing melanoma, squamous cell cancer of the head and neck or non-small cell lung…
Background MGA271 is an Fc optimized, humanized IgG1 monoclonal antibody targeting B7-H3 (CD276), a member of the B7 family, and… (More)
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2012
2012
Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity.
PURPOSE The goal of this research was to harness a monoclonal antibody (mAb) discovery platform to identify cell-surface antigens… (More)
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2012
2012
Cancer Therapy : Preclinical Development of an Fc-Enhanced Anti – B 7-H 3 Monoclonal Antibody with Potent Antitumor Activity
Purpose: The goal of this research was to harness a monoclonal antibody (mAb) discovery platform to identify cell-surface… (More)
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