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Monoclonal Antibody M-T412

Known as: M-T412, MoAb M-T412 
A chimeric murine-human anti-CD4 monoclonal antibody that down regulates T-helper-inducer function. Clinical Trails: Multiple Sclerosis.
National Institutes of Health

Related topics

Related topics

1 relation
antigen binding

Papers overview

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1994
1994
Expression and characterization of cM-T413, a chimeric anti-CD4 antibody with in vitro immunosuppressive activity.
Anti-CD4 monoclonal antibodies (mAbs) have shown considerable promise in the treatment of rheumatoid arthritis, psoriasis, and… 
1993
1993
Effects of isotype and Fc region on in vitro function of a mouse/human chimeric CD4 antibody.
Murine CD4 mAbs have shown potential for the treatment of allograft rejection and autoimmune disorders including rheumatoid… 
1993
1993
In vivo treatment with a monoclonal chimeric anti‐CD4 antibody results in prolonged depletion of circulating CD4+ cells in chimpanzees
Chimeric M‐T412 (cM‐T412). an anti‐CD4 antibody, was tolerated in chimpanzees at a dosage of 5 mg/kg per day for up to 7… 
1992
1992
A Cys138-to-Arg substitution in the GM2 activator protein is associated with the AB variant form of GM2 gangliosidosis.
The AB-variant form of GM2 gangliosidosis is an inherited lysosomal storage disease. Biochemical data have linked its cause to… 
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