Molecular Target

Every point of difference between premalignant or malignant cells and their normal counterparts is a potential target of opportunity for drug… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
MicroRNAs (miRNA) are non-coding RNAs, approximately 22 nucleotides in length, which function as post-transcriptional regulators… (More)
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Highly Cited
2009
Highly Cited
2009
Because the p300/CBP-mediated hyperacetylation of RelA (p65) is critical for nuclear factor-kappaB (NF-kappaB) activation, the… (More)
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2009
2009
Breast cancers can be classified into those that express the estrogen (ER) and progesterone (PR) receptors, those with ERBB2 (HER… (More)
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Review
2007
Review
2007
Survivin is a bifunctional protein that acts as a suppressor of apoptosis and plays a central role in cell division. The protein… (More)
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2006
2006
The low density lipoprotein (LDL) receptor has been shown to be upregulated in GBM tumor cells and is therefore a potential… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE Currently available clinical and molecular factors provide still an insufficient prognostic and predictive assessment… (More)
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Highly Cited
2003
Highly Cited
2003
We have previously identified SU(Z)12 as an E2F target gene. Because many E2F target genes encode proteins that are critical for… (More)
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Highly Cited
2003
Highly Cited
2003
In this study, we show that LIM kinase 1 (LIMK1), a critical regulator of actin dynamics, plays a regulatory role in tumor cell… (More)
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Highly Cited
2000
Highly Cited
2000
Retigabine is a novel anticonvulsant with an unknown mechanism of action. It has recently been reported that retigabine modulates… (More)
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Highly Cited
1999
Highly Cited
1999
Whereas signal transducers and activators of transcription were originally discovered as mediators of normal cytokine signaling… (More)
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