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Minodronic Acid

National Institutes of Health

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YM 529

Papers overview

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2017
2017
Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors
Minodronic acid is an aminobisphosphonate that is an antagonist of purinergic P2X2/3 receptors involved in pain. The aim of this… 
2016
2016
Minodronic acid suppresses gonadotropin-releasing hormone agonist-induced bone remodeling biomarkers: a retrospective pilot study
Abstract Background: Estrogen deprivation therapy for myoma/adenomyosis decreases bone mineral density and can only be applied in… 
2015
2015
On-cartridge derivatization coupled with solid-phase extraction for the ultra-sensitive determination of minodronic acid in human plasma by LC-MS/MS method.
Review
2011
Review
2011
[Minodronic acid- its clinical efficacy and prospects for once-a-month dosing regimen].
Minodronic acid has been developed and approved for the treatment of osteoporosis in Japan. It was reported that daily 1 mg… 
Highly Cited
2010
Highly Cited
2010
Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2…
3-(3-Pyridyl)-2-hydroxy-2-phosphonopropanoic acid (3-PEHPC, 1) is a phosphonocarboxylate (PC) analogue of 2-(3-pyridyl)-1… 
2008
2008
Long-term minodronic acid (ONO-5920/YM529) treatment suppresses increased bone turnover, plus prevents reduction in bone mass and bone strength in ovariectomized rats with established osteopenia.
2005
2005
A Third-Generation Bisphosphonate, Minodronic Acid (YM529), Augments the Interferon α/β-Mediated Inhibition of Renal Cell Cancer Cell Growth Both In vitro and In vivo
Purpose: Minodronic acid (YM529) is a third-generation nitrogen-containing bisphosphonate. Here, we have investigated the… 
2005
2005
A third-generation bisphosphonate, minodronic acid (YM529), augments the interferon alpha/beta-mediated inhibition of renal cell cancer cell growth both in vitro and in vivo.
PURPOSE Minodronic acid (YM529) is a third-generation nitrogen-containing bisphosphonate. Here, we have investigated the… 
2003
2003
Effect of minodronic acid (ONO-5920) on bone mineral density and arthritis in adult rats with collagen-induced arthritis.
OBJECTIVE To study the effect of minodronic acid (ONO-5920) on bone loss and arthritis in rats with collagen-induced arthritis… 
2002
2002
Failure of stability prediction for minodronic acid injectable by accelerated stability testing.
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