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BackgroundSystemic sclerosis is a systemic connective tissue disease characterized by endothelium damage, fibrosis, and… Expand BackgroundSystemic sclerosis (SSc) is an autoimmune disease with multisystem involvement, dominated by a general fibrosis. The… Expand No Level Assigned This journal requires that authors assign a level of evidence to each article. For a full description of these… Expand Background. Systemic sclerosis (SSc) is a multisystem disease characterized by cutaneous and visceral fibrosis. Face and mouth… Expand Orofacial manifestations due to fibrosis of the skin and soft tissues are typical in SSc and include amimia, disappearance of… Expand SummaryA child born in 1948 with rare multiple deformities first underwent operative correction of polysyndactyly of both hands… Expand